Two dimensional in silico simulations.

Snapshots of the spread of an oncolytic virus in a 2D environment with a regular lattice architecture (A-D) having n = 4 nearest neighbors and with a Voronoi lattice (E–H) with n = 6 nearest neighbors. In both scenarios, there is one major focus of infection as in the equivalent in vitro scenario. Blue represents normal cells, red represents tumor cells, green represents infected tumor cells and black represents empty space.