Additional file 7: of Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment

Wanfu Xu (4796367)
Jiabi Qian (6431336)
Fangyin Zeng (6431339)
Songyu Li (6431345)
Wenjing Guo (676944)
Liping Chen (119540)
Guihuan Li (795334)
Zhishuai Zhang (6431348)
Qiming Wang (730892)
Fan Deng (699529)

Publication date

March 2019

DOI

10.6084/m9.figshare.7812923.v1

Abstract

Figure S5. PKD2/3 silencing of prostate cancer cells reduced angiogenic factor expression in P815 MCs cells. (PDF 785 kb

Extracted data

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Additional file 7: of Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment

Wanfu Xu (4796367)
Jiabi Qian (6431336)
Fangyin Zeng (6431339)
Songyu Li (6431345)
Wenjing Guo (676944)
Liping Chen (119540)
Guihuan Li (795334)
Zhishuai Zhang (6431348)
Qiming Wang (730892)
Fan Deng (699529)

Open link

Publication date

March 2019

DOI

10.6084/m9.figshare.7812923.v1

Abstract

Figure S5. PKD2/3 silencing of prostate cancer cells reduced angiogenic factor expression in P815 MCs cells. (PDF 785 kb

Extracted data

Juan Lu (275293)
Qi-Hui Liu (5510840)
Fan Wang (135182)
Jia-Jie Tan (5510837)
Yue-Qin Deng (5510843)
Xiao-Hong Peng (2421310)
Xiong Liu (43564)
Bao Zhang (186933)
Xia Xu (83500)
Xiang-Ping Li (538566)

July 2018

Figure S4. MDK expression was significantly downregulated after siMDK transfection in HUVEC cells. (...

Additional file 6: Figure S6. of PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation

Ninel Azoitei (3768187)
Alexander Becher (3768193)
Konrad Steinestel (152183)
Arefeh Rouhi (3768184)
Kristina Diepold (3768190)
Felicitas Genze (203267)
Thomas Simmet (67634)
Thomas Seufferlein (232037)

January 2016

PKM2 mediates hypoxia-triggered VEGF-A secretion by activation of NF-κB/p65 subunit. A, western blot...

Additional file 4: of Protein kinase C inhibitor Gรถ6976 but not Gรถ6983 induces the reversion of E- to N-cadherin switch and metastatic phenotype in melanoma: identification of the role of protein kinase D1

Messaouda Merzoug-Larabi (3619421)
Caroline Spasojevic (3619418)
Marianne Eymard (3619409)
Caroline Hugonin (3619415)
Christian Auclair (140039)
Manale Karam (3619412)

January 2017

PKD1 knockdown induces the expression of E-cadherin and inhibits the expression of N-cadherin in M4T...

Additional file 8: of Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment

Wanfu Xu (4796367)
Jiabi Qian (6431336)
Fangyin Zeng (6431339)
Songyu Li (6431345)
Wenjing Guo (676944)
Liping Chen (119540)
Guihuan Li (795334)
Zhishuai Zhang (6431348)
Qiming Wang (730892)
Fan Deng (699529)

March 2019

Figure S6. SCF, CCL5, and CCL11 rescued MCs migration inhibited by CM from PC-3M cells with PKD sile...

Additional file 5: of Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment

Wanfu Xu (4796367)
Jiabi Qian (6431336)
Fangyin Zeng (6431339)
Songyu Li (6431345)
Wenjing Guo (676944)
Liping Chen (119540)
Guihuan Li (795334)
Zhishuai Zhang (6431348)
Qiming Wang (730892)
Fan Deng (699529)

March 2019

Figure S3. PKD2/3 in prostate cancer cells promoted chemotactic migration of mast cells. (PDF 1025 k...

Additional file 6: of Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment

Wanfu Xu (4796367)
Jiabi Qian (6431336)
Fangyin Zeng (6431339)
Songyu Li (6431345)
Wenjing Guo (676944)
Liping Chen (119540)
Guihuan Li (795334)
Zhishuai Zhang (6431348)
Qiming Wang (730892)
Fan Deng (699529)

March 2019

Figure S4. Effect of PKD2 and PKD3 derived prostate cancer cells on endothelial cells tube formation...

Additional file 10: of Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment

Wanfu Xu (4796367)
Jiabi Qian (6431336)
Fangyin Zeng (6431339)
Songyu Li (6431345)
Wenjing Guo (676944)
Liping Chen (119540)
Guihuan Li (795334)
Zhishuai Zhang (6431348)
Qiming Wang (730892)
Fan Deng (699529)

March 2019

Figure S8. PKD2/3 modulated Erk1/2 and NF-ÎşB activity in prostate cancer cells in response to PMA. ...

Additional file 3: Figure S3. of PKM2 promotes tumor angiogenesis by regulating HIF-1Îą through NF-ÎşB activation

Ninel Azoitei (3768187)
Alexander Becher (3768193)
Konrad Steinestel (152183)
Arefeh Rouhi (3768184)
Kristina Diepold (3768190)
Felicitas Genze (203267)
Thomas Simmet (67634)
Thomas Seufferlein (232037)

January 2016

PKM2 abrogation results in decreased blood vessel formation in vivo. IHC of BxPC3 pancreatic cancer ...

Additional file 5: of PAGE4 promotes prostate cancer cells survive under oxidative stress through modulating MAPK/JNK/ERK pathway

Chengcheng Lv (6245279)
Shui Fu (6245282)
Qingzhuo Dong (6245285)
Zi Yu (6245288)
Gejun Zhang (6245291)
Chuize Kong (4118263)
Cheng Fu (643693)
Yu Zeng (67023)

January 2019

Figure S3. PAGE4 shows low tumor malignancy. a Heat map for several prostate cancer malignancy relat...

Additional file 5: Figure S5. of PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation

Ninel Azoitei (3768187)
Alexander Becher (3768193)
Konrad Steinestel (152183)
Arefeh Rouhi (3768184)
Kristina Diepold (3768190)
Felicitas Genze (203267)
Thomas Simmet (67634)
Thomas Seufferlein (232037)

January 2016

PKM2 regulates hypoxia-induced VEGF promoter activity. A, PaTu2 cancer cells were transiently transf...

Additional file 7: of Metabolic reprogramming-based characterization of circulating tumor cells in prostate cancer

Jing Chen (4762)
Shunwang Cao (5338076)
Bo Situ (4682563)
Juan Zhong (486982)
Yanwei Hu (766578)
Shufen Li (746508)
Jinlan Huang (4615594)
Jiasen Xu (729951)
Shiyang Wu (729947)
Jinduan Lin (5338073)
Qianwen Zhao (5467433)
Zhen Cai (576458)
Lei Zheng (106363)
Qian Wang (32718)

June 2018

Figure S2. Functions of the differentially expressed genes in glucose and glycogen metabolism. These...

Additional file 1: of PKN2 in colon cancer cells inhibits M2 phenotype polarization of tumor-associated macrophages via regulating DUSP6-Erk1/2 pathway

Yang Cheng (125394)
Yun Zhu (46269)
Jiajia Xu (688438)
Min Yang (146229)
Peiyu Chen (3107730)
Wanfu Xu (4796367)
Junhong Zhao (4796364)
Lanlan Geng (4796370)
Sitang Gong (4796361)

January 2018

Table S1. KEGG pathway analysis of differentially expressed genes in colon cancer cells with differe...

Additional file 15: of Downregulation of miR-133a-3p promotes prostate cancer bone metastasis via activating PI3K/AKT signaling

Yubo Tang (350759)
Jincheng Pan (461203)
Shuai Huang (60512)
Xinsheng Peng (350750)
Xuenong Zou (291919)
Yongxiang Luo (1492720)
Dong Ren (135842)
Xin Zhang (35492)
Ronggang Li (4399720)
Peiheng He (5534342)
Qingde Wa (4641736)

July 2018

Figure S7. (A-C) ELISA analysis of EGF, bFGF, IGF1, IGF2, NGF and HGF concentration in the supernata...

Additional file 1: Figure S1. of Thrombospondin-2 promotes prostate cancer bone metastasis by the up-regulation of matrix metalloproteinase-2 through down-regulating miR-376c expression

Po-Chun Chen (1878085)
Chih-Hsin Tang (104506)
Liang-Wei Lin (3696037)
Chun-Hao Tsai (296997)
Cheng-Ying Chu (511809)
Tien-Huang Lin (631773)
Yuan-Li Huang (296995)

January 2017

TSP-2 induces MMP-2 and inhibits miR-376c expressionsin LNCaP cells. Figure S2. The siRNAs abolished...

Additional file 4: of Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1Îą/VEGF signalling in MCF-7 breast cancer cells

Valerio Ciccone (6080381)
Erika Terzuoli (315407)
Sandra Donnini (315416)
Antonio Giachetti (315414)
Lucia Morbidelli (2219674)
Marina Ziche (315415)

December 2018

Table S2. Angiogenic factors release evaluated by ELISA plate array in supernatants of MCF-7 treated...

Additional file 5: of Exosomal miR-9 inhibits angiogenesis by targeting MDK and regulating PDK/AKT pathway in nasopharyngeal carcinoma

Juan Lu (275293)
Qi-Hui Liu (5510840)
Fan Wang (135182)
Jia-Jie Tan (5510837)
Yue-Qin Deng (5510843)
Xiao-Hong Peng (2421310)
Xiong Liu (43564)
Bao Zhang (186933)
Xia Xu (83500)
Xiang-Ping Li (538566)

July 2018

Figure S4. MDK expression was significantly downregulated after siMDK transfection in HUVEC cells. (...

Additional file 6: Figure S6. of PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation

Ninel Azoitei (3768187)
Alexander Becher (3768193)
Konrad Steinestel (152183)
Arefeh Rouhi (3768184)
Kristina Diepold (3768190)
Felicitas Genze (203267)
Thomas Simmet (67634)
Thomas Seufferlein (232037)

January 2016

PKM2 mediates hypoxia-triggered VEGF-A secretion by activation of NF-κB/p65 subunit. A, western blot...

Messaouda Merzoug-Larabi (3619421)
Caroline Spasojevic (3619418)
Marianne Eymard (3619409)
Caroline Hugonin (3619415)
Christian Auclair (140039)
Manale Karam (3619412)

January 2017

PKD1 knockdown induces the expression of E-cadherin and inhibits the expression of N-cadherin in M4T...

Additional file 8: of Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment

Wanfu Xu (4796367)
Jiabi Qian (6431336)
Fangyin Zeng (6431339)
Songyu Li (6431345)
Wenjing Guo (676944)
Liping Chen (119540)
Guihuan Li (795334)
Zhishuai Zhang (6431348)
Qiming Wang (730892)
Fan Deng (699529)

March 2019

Figure S6. SCF, CCL5, and CCL11 rescued MCs migration inhibited by CM from PC-3M cells with PKD sile...

Additional file 5: of Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment

Wanfu Xu (4796367)
Jiabi Qian (6431336)
Fangyin Zeng (6431339)
Songyu Li (6431345)
Wenjing Guo (676944)
Liping Chen (119540)
Guihuan Li (795334)
Zhishuai Zhang (6431348)
Qiming Wang (730892)
Fan Deng (699529)

March 2019

Figure S3. PKD2/3 in prostate cancer cells promoted chemotactic migration of mast cells. (PDF 1025 k...

Additional file 6: of Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment

Wanfu Xu (4796367)
Jiabi Qian (6431336)
Fangyin Zeng (6431339)
Songyu Li (6431345)
Wenjing Guo (676944)
Liping Chen (119540)
Guihuan Li (795334)
Zhishuai Zhang (6431348)
Qiming Wang (730892)
Fan Deng (699529)

March 2019

Figure S4. Effect of PKD2 and PKD3 derived prostate cancer cells on endothelial cells tube formation...

Additional file 10: of Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment

Wanfu Xu (4796367)
Jiabi Qian (6431336)
Fangyin Zeng (6431339)
Songyu Li (6431345)
Wenjing Guo (676944)
Liping Chen (119540)
Guihuan Li (795334)
Zhishuai Zhang (6431348)
Qiming Wang (730892)
Fan Deng (699529)

March 2019

Figure S8. PKD2/3 modulated Erk1/2 and NF-ÎşB activity in prostate cancer cells in response to PMA. ...

Additional file 3: Figure S3. of PKM2 promotes tumor angiogenesis by regulating HIF-1Îą through NF-ÎşB activation

Ninel Azoitei (3768187)
Alexander Becher (3768193)
Konrad Steinestel (152183)
Arefeh Rouhi (3768184)
Kristina Diepold (3768190)
Felicitas Genze (203267)
Thomas Simmet (67634)
Thomas Seufferlein (232037)

January 2016

PKM2 abrogation results in decreased blood vessel formation in vivo. IHC of BxPC3 pancreatic cancer ...

Additional file 5: of PAGE4 promotes prostate cancer cells survive under oxidative stress through modulating MAPK/JNK/ERK pathway

Chengcheng Lv (6245279)
Shui Fu (6245282)
Qingzhuo Dong (6245285)
Zi Yu (6245288)
Gejun Zhang (6245291)
Chuize Kong (4118263)
Cheng Fu (643693)
Yu Zeng (67023)

January 2019

Figure S3. PAGE4 shows low tumor malignancy. a Heat map for several prostate cancer malignancy relat...

Additional file 5: Figure S5. of PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation

Ninel Azoitei (3768187)
Alexander Becher (3768193)
Konrad Steinestel (152183)
Arefeh Rouhi (3768184)
Kristina Diepold (3768190)
Felicitas Genze (203267)
Thomas Simmet (67634)
Thomas Seufferlein (232037)

January 2016

PKM2 regulates hypoxia-induced VEGF promoter activity. A, PaTu2 cancer cells were transiently transf...

Additional file 7: of Metabolic reprogramming-based characterization of circulating tumor cells in prostate cancer

Jing Chen (4762)
Shunwang Cao (5338076)
Bo Situ (4682563)
Juan Zhong (486982)
Yanwei Hu (766578)
Shufen Li (746508)
Jinlan Huang (4615594)
Jiasen Xu (729951)
Shiyang Wu (729947)
Jinduan Lin (5338073)
Qianwen Zhao (5467433)
Zhen Cai (576458)
Lei Zheng (106363)
Qian Wang (32718)

June 2018

Figure S2. Functions of the differentially expressed genes in glucose and glycogen metabolism. These...

Additional file 1: of PKN2 in colon cancer cells inhibits M2 phenotype polarization of tumor-associated macrophages via regulating DUSP6-Erk1/2 pathway

Yang Cheng (125394)
Yun Zhu (46269)
Jiajia Xu (688438)
Min Yang (146229)
Peiyu Chen (3107730)
Wanfu Xu (4796367)
Junhong Zhao (4796364)
Lanlan Geng (4796370)
Sitang Gong (4796361)

January 2018

Table S1. KEGG pathway analysis of differentially expressed genes in colon cancer cells with differe...

Additional file 15: of Downregulation of miR-133a-3p promotes prostate cancer bone metastasis via activating PI3K/AKT signaling

Yubo Tang (350759)
Jincheng Pan (461203)
Shuai Huang (60512)
Xinsheng Peng (350750)
Xuenong Zou (291919)
Yongxiang Luo (1492720)
Dong Ren (135842)
Xin Zhang (35492)
Ronggang Li (4399720)
Peiheng He (5534342)
Qingde Wa (4641736)

July 2018

Figure S7. (A-C) ELISA analysis of EGF, bFGF, IGF1, IGF2, NGF and HGF concentration in the supernata...

Additional file 1: Figure S1. of Thrombospondin-2 promotes prostate cancer bone metastasis by the up-regulation of matrix metalloproteinase-2 through down-regulating miR-376c expression

Po-Chun Chen (1878085)
Chih-Hsin Tang (104506)
Liang-Wei Lin (3696037)
Chun-Hao Tsai (296997)
Cheng-Ying Chu (511809)
Tien-Huang Lin (631773)
Yuan-Li Huang (296995)

January 2017

TSP-2 induces MMP-2 and inhibits miR-376c expressionsin LNCaP cells. Figure S2. The siRNAs abolished...

Additional file 4: of Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1Îą/VEGF signalling in MCF-7 breast cancer cells

Valerio Ciccone (6080381)
Erika Terzuoli (315407)
Sandra Donnini (315416)
Antonio Giachetti (315414)
Lucia Morbidelli (2219674)
Marina Ziche (315415)

December 2018

Table S2. Angiogenic factors release evaluated by ELISA plate array in supernatants of MCF-7 treated...

Additional file 5: of Exosomal miR-9 inhibits angiogenesis by targeting MDK and regulating PDK/AKT pathway in nasopharyngeal carcinoma

Juan Lu (275293)
Qi-Hui Liu (5510840)
Fan Wang (135182)
Jia-Jie Tan (5510837)
Yue-Qin Deng (5510843)
Xiao-Hong Peng (2421310)
Xiong Liu (43564)
Bao Zhang (186933)
Xia Xu (83500)
Xiang-Ping Li (538566)

July 2018

Figure S4. MDK expression was significantly downregulated after siMDK transfection in HUVEC cells. (...

Additional file 6: Figure S6. of PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation

Ninel Azoitei (3768187)
Alexander Becher (3768193)
Konrad Steinestel (152183)
Arefeh Rouhi (3768184)
Kristina Diepold (3768190)
Felicitas Genze (203267)
Thomas Simmet (67634)
Thomas Seufferlein (232037)

January 2016

PKM2 mediates hypoxia-triggered VEGF-A secretion by activation of NF-κB/p65 subunit. A, western blot...

Messaouda Merzoug-Larabi (3619421)
Caroline Spasojevic (3619418)
Marianne Eymard (3619409)
Caroline Hugonin (3619415)
Christian Auclair (140039)
Manale Karam (3619412)

January 2017

PKD1 knockdown induces the expression of E-cadherin and inhibits the expression of N-cadherin in M4T...

Additional file 7: of Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment

Abstract

Extracted data

Additional file 7: of Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment

Abstract

Extracted data

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