Angiotensin II (AngII)-activated epidermal growth factor receptor has been implicated in abdominal aortic aneurysm (AAA) development. In vascular smooth muscle cells (VSMCs), AngII activates epidermal growth factor receptor via a metalloproteinase, ADAM17 (a disintegrin and metalloproteinase domain 17). We hypothesized that AngII-dependent AAA development would be prevented in mice lacking ADAM17 in VSMCs. To test this concept, control and VSMC ADAM17-deficient mice were cotreated with AngII and a lysyl oxidase inhibitor, β-aminopropionitrile, to induce AAA. We found that 52.4% of control mice did not survive because of aortic rupture. All other surviving control mice developed AAA and demonstrated enhanced expression of ADAM17 in the AAA l...
Background-—The progression of abdominal aortic aneurysm (AAA) involves a sustained influx of proinf...
AT2 receptors have an unclear function on development of abdominal aortic aneurysms (AAAs), although...
Objective—Abdominal aortic aneurysm (AAA) is a life-threatening disease affecting almost 10 % of the...
Angiotensin II (AngII)-activated epidermal growth factor receptor has been implicated in abdominal a...
Angiotensin II (AngII) has been strongly implicated in hypertension and its complications. Evidence ...
Although AngII (angiotensin II) and its receptor AT1R (AngII type 1 receptor) have been implicated i...
Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. Chronic inflamma...
BACKGROUND: Abdominal aortic aneurysm (AAA) is an inflammatory disorder characterized by a localized...
BackgroundComplicated aortic aneurysm is a major cause of mortality in elderly men. The critical pat...
OBJECTIVE: Thoracic aortic aneurysm (TAA), a degenerative disease of the aortic wall, is accompanied...
Abdominal aortic aneurysm (AAA) is a major cause of morbidity and mortality; however, the mechanisms...
Abdominal aortic aneurysm (AAA) refers to a localized dilation of the abdominal aorta that exceeds t...
Abdominal aortic aneurysm (AAA) is an abnormal dilatation of the aorta that is permanent and progres...
Thoracic aortic aneurysm (TAA) involves extracellular matrix (ECM) remodeling of the aortic wall, le...
ObjectiveAbdominal aortic aneurysm (AAA) development is associated with increased angiogenesis and o...
Background-—The progression of abdominal aortic aneurysm (AAA) involves a sustained influx of proinf...
AT2 receptors have an unclear function on development of abdominal aortic aneurysms (AAAs), although...
Objective—Abdominal aortic aneurysm (AAA) is a life-threatening disease affecting almost 10 % of the...
Angiotensin II (AngII)-activated epidermal growth factor receptor has been implicated in abdominal a...
Angiotensin II (AngII) has been strongly implicated in hypertension and its complications. Evidence ...
Although AngII (angiotensin II) and its receptor AT1R (AngII type 1 receptor) have been implicated i...
Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. Chronic inflamma...
BACKGROUND: Abdominal aortic aneurysm (AAA) is an inflammatory disorder characterized by a localized...
BackgroundComplicated aortic aneurysm is a major cause of mortality in elderly men. The critical pat...
OBJECTIVE: Thoracic aortic aneurysm (TAA), a degenerative disease of the aortic wall, is accompanied...
Abdominal aortic aneurysm (AAA) is a major cause of morbidity and mortality; however, the mechanisms...
Abdominal aortic aneurysm (AAA) refers to a localized dilation of the abdominal aorta that exceeds t...
Abdominal aortic aneurysm (AAA) is an abnormal dilatation of the aorta that is permanent and progres...
Thoracic aortic aneurysm (TAA) involves extracellular matrix (ECM) remodeling of the aortic wall, le...
ObjectiveAbdominal aortic aneurysm (AAA) development is associated with increased angiogenesis and o...
Background-—The progression of abdominal aortic aneurysm (AAA) involves a sustained influx of proinf...
AT2 receptors have an unclear function on development of abdominal aortic aneurysms (AAAs), although...
Objective—Abdominal aortic aneurysm (AAA) is a life-threatening disease affecting almost 10 % of the...