Glomerular filtration rate is reduced in female offspring regardless of birth weight whereas renal function is not altered by uninephrectomy in male rats.

Male data are shown in the left-sided panel, and female data are shown on the right. (A-B) GFR does not differ in male offspring, but GFR is significantly decreased in female control and growth-restricted offspring after uninephrectomy relative to sham counterparts. (C-D) Serum creatinine does not differ in male offspring, but is increased in female control and growth-restricted offspring after uninephrectomy relative to sham counterparts. (E-F) Blood urea nitrogen is similar between all groups. All groups were compared to same-sex counterparts. *P<0.05 vs sham counterpart. BUN, blood urea nitrogen; GFR, glomerular filtration rate; IUGR, intrauterine growth restricted; UNI-X, uninephrectomized. GFR sample sizes, males: control sham = 4, control UNI-X = 4, IUGR sham = 5, IUGR UNI-X = 4. GFR sample sizes, females: control sham = 5, control UNI-X = 5, IUGR sham = 7, IUGR UNI-X = 5. Creatinine sample sizes, males: control sham = 5, control UNI-X = 7, IUGR sham = 5, IUGR UNI-X = 7. Creatinine sample sizes, females: control sham = 7, control UNI-X = 6, IUGR sham = 10, IUGR UNI-X = 7. BUN sample sizes, males: control sham = 5, control UNI-X = 7, IUGR sham = 5, IUGR UNI-X = 8. BUN sample sizes, females: control sham = 7, control UNI-X = 6, IUGR sham = 10, IUGR UNI-X = 6.