Comparisons of motifs with different complexity and types.

A. Two specific network topologies were selected for comparing models with different complexity. Network 1 contains multiple Type I motifs, whereas Network 2 is a single Type I motif. The color code of the complexity atlas is the same as that in Fig 2 and Fig 4. Red: Type I motif. Blue: Type II motif. Green: Hybrid motif. B. Performances of the two subnetworks are compared. Performance was quantified with the sum of squared distance (SSD) from a predefined hypothetical continuous production function (gray curve) of PU.1 level that have 7 intersections with the degradation function, which generates four attractors (see details in supplementary text). The purple and red curves represent the optimized functions fitted to the gray curve. The gray curve is closer to the purple curve than to the red curve, suggesting a better fit with Network 1. C. SSD values obtained from 500 optimization runs for each of Network 1 and Network 2. Each value was calculated using the procedure shown in B. D. Numbers of parameter sets that generate the four-attractor systems per 106 random samples per topology. Three types of network motifs with 7 regulations are compared.