Quantitative cell-based model predicts mechanical stress response of growing tumor spheroids over various growth conditions and cell lines - Fig 11

(top) (A) Time evolution of the radius of the thin capsule, shown for the experimental data and simulations using Model I, showing the effect of a parameter variation for the lysis time Tlys. (B) Time evolution of the simulated cell density. (C) Cell density at 48h obtained from final model run with optimal parameters, but in which cells divide after a fixed cycle time (”timer“) instead of a fixed size.