Purkinje post–complex spike pauses act as a gating mechanism for early coarse VOR in the absence of cerebellar adaptation.

Only half of h-VOR cycle is represented. Two equal cerebellar network configurations except for the Purkinje cell dynamics were compared under equal stimulation. (A) The first model accounts for CF-evoked Purkinje spike burst-pause dynamics. CF stimulation generates complex spikes and subsequent post–complex spike pauses. The latter allows MFs to drive directly the immediate activation of MVN, which facilitates an early but rough eye movement compensation for head velocity. (B) The second model only exhibits Purkinje tonic firing (i.e., complex spiking is blocked through the blockade of muscarinic voltage-dependent channels, see Methods), which prevents MFs from eliciting any baseline MVN compensatory output. See S2 and S3 Figs for a sensitivity analysis of parameters regulating the LTD/LTP balance at PF-Purkinje cell and MF-MVN synapses. See also S4 Fig for the same parameter sensitivity analysis in the absence of Purkinje spike burst-pause dynamics.