A Mild, DNA-Compatible Nitro Reduction Using B<sub>2</sub>(OH)<sub>4</sub>
- Huang-Chi Du (4432291)
- Nicholas Simmons (2408128)
- John C. Faver (223520)
- Zhifeng Yu (644059)
- Murugesan Palaniappan (5029727)
- Kevin Riehle (158334)
- Martin M. Matzuk (200210)
Publication date
March 2019
DOI Publisher
American Chemical Society (ACS)Abstract
A hypodiboric acid system for the reduction of nitro groups on DNA–chemical conjugates has been developed. This transformation provided good to excellent yields of the reduced amine product for a variety of functionalized aromatic, heterocyclic, and aliphatic nitro compounds. DNA tolerance to reaction conditions, extension to decigram scale reductions, successful use in a DNA-encoded chemical library synthesis, and subsequent target selection are also described
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