DIAVIT protects against diabetes-induced glomerular ultra-structural changes.

A) Representative glomerular electron micrographs from lean, db/db, and db/db + DIAVIT mice. Diabetic db/db glomeruli shows evidence of MME, which is not apparent in lean or db/db + DIAVIT glomeruli. Diabetic db/db glomeruli developed an increased GBM width (B), decreased number of endothelial fenestrations (C) and podocyte foot processes (D) per μm length, and an increased average podocyte foot process width (E) compared to lean controls (*pB), number of endothelial fenestrations per μm length (c), and average podocyte foot process width (E) in db/db + DIAVIT glomeruli (†pD) (*p<0.05 vs lean) (n = 3 mice; One-way ANOVA with Bonferroni post-hoc test for comparison between pairs).