Additional file 12: of Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Doyle, Stephen R.
Illingworth, Christopher J.R.
Laing, Roz
Bartley, David J.
Redman, Elizabeth
Martinelli, Axel
Holroyd, Nancy
Morrison, Alison A.
Rezansoff, Andrew
Tracey, Alan
Devaney, Eileen
Berriman, Matthew
Sargison, Neil
Cotton, James A.
Gilleard, John S.

March 2019

BACKGROUND:Infections with helminths cause an enormous disease burden in billions of animals and pla...

Evidence from two independent backcross experiments supports genetic linkage of microsatellite Hcms8a20, but not other candidate loci, to a major ivermectin resistance locus in Haemonchus contortus

Rezansoff, Andrew M.
Laing, Roz
Gilleard, John S.

September 2016

Haemonchus contortus is the leading parasitic nematode species used to study anthelmintic drug resis...

Genome-wide analysis of the response to ivermectin treatment by a Swedish field population of Haemonchus contortus

Baltrusis, Paulius
Doyle, Stephen R.
Halvarsson, Peter
Höglund, Johan

January 2022

Haemonchus contortus is a pathogenic gastrointestinal nematode of small ruminants and, in part due t...

Additional file 10: of Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Stephen Doyle (1420624)
Christopher Illingworth (6472265)
Roz Laing (183493)
David Bartley (3028725)
Elizabeth Redman (183534)
Axel Martinelli (252562)
Nancy Holroyd (192338)
Alison Morrison (183550)
Andrew Rezansoff (6472268)
Alan Tracey (6472271)
Eileen Devaney (364093)
Matthew Berriman (5353)
Neil Sargison (183538)
James Cotton (27635)
John Gilleard (3400712)

March 2019

Figure S8. Contour maps of log likelihood scores derived from the two locus driver model. A. MHco10(...

Additional file 8: of Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Stephen Doyle (1420624)
Christopher Illingworth (6472265)
Roz Laing (183493)
David Bartley (3028725)
Elizabeth Redman (183534)
Axel Martinelli (252562)
Nancy Holroyd (192338)
Alison Morrison (183550)
Andrew Rezansoff (6472268)
Alan Tracey (6472271)
Eileen Devaney (364093)
Matthew Berriman (5353)
Neil Sargison (183538)
James Cotton (27635)
John Gilleard (3400712)

March 2019

Figure S9. Relative position and location of candidate genes from the literature proposed to be asso...

Additional file 2: of Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Stephen Doyle (1420624)
Christopher Illingworth (6472265)
Roz Laing (183493)
David Bartley (3028725)
Elizabeth Redman (183534)
Axel Martinelli (252562)
Nancy Holroyd (192338)
Alison Morrison (183550)
Andrew Rezansoff (6472268)
Alan Tracey (6472271)
Eileen Devaney (364093)
Matthew Berriman (5353)
Neil Sargison (183538)
James Cotton (27635)
John Gilleard (3400712)

March 2019

Figure S2. Distribution of âprivateâ variant sites per parental population. A. MHco3(ISE). B. MH...

Additional file 9: of Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Stephen Doyle (1420624)
Christopher Illingworth (6472265)
Roz Laing (183493)
David Bartley (3028725)
Elizabeth Redman (183534)
Axel Martinelli (252562)
Nancy Holroyd (192338)
Alison Morrison (183550)
Andrew Rezansoff (6472268)
Alan Tracey (6472271)
Eileen Devaney (364093)
Matthew Berriman (5353)
Neil Sargison (183538)
James Cotton (27635)
John Gilleard (3400712)

March 2019

Figure S10. Haplotype structure of chromosome V in an example output from the model under neutral ev...

Additional file 11: of Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Stephen Doyle (1420624)
Christopher Illingworth (6472265)
Roz Laing (183493)
David Bartley (3028725)
Elizabeth Redman (183534)
Axel Martinelli (252562)
Nancy Holroyd (192338)
Alison Morrison (183550)
Andrew Rezansoff (6472268)
Alan Tracey (6472271)
Eileen Devaney (364093)
Matthew Berriman (5353)
Neil Sargison (183538)
James Cotton (27635)
John Gilleard (3400712)

March 2019

Figure S5. Fits between the model and the data for each data sample. Blue dots show filtered allele ...

Additional file 1: of Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Stephen Doyle (1420624)
Christopher Illingworth (6472265)
Roz Laing (183493)
David Bartley (3028725)
Elizabeth Redman (183534)
Axel Martinelli (252562)
Nancy Holroyd (192338)
Alison Morrison (183550)
Andrew Rezansoff (6472268)
Alan Tracey (6472271)
Eileen Devaney (364093)
Matthew Berriman (5353)
Neil Sargison (183538)
James Cotton (27635)
John Gilleard (3400712)

March 2019

Figure S1. Characterisation of within-population diversity. A. Within population nucleotide diversit...

Additional file 5: of Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Stephen Doyle (1420624)
Christopher Illingworth (6472265)
Roz Laing (183493)
David Bartley (3028725)
Elizabeth Redman (183534)
Axel Martinelli (252562)
Nancy Holroyd (192338)
Alison Morrison (183550)
Andrew Rezansoff (6472268)
Alan Tracey (6472271)
Eileen Devaney (364093)
Matthew Berriman (5353)
Neil Sargison (183538)
James Cotton (27635)
John Gilleard (3400712)

March 2019

Figure S6. Location of significantly non-neutral loci identified using the single-locus population g...

Additional file 4: of Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Stephen Doyle (1420624)
Christopher Illingworth (6472265)
Roz Laing (183493)
David Bartley (3028725)
Elizabeth Redman (183534)
Axel Martinelli (252562)
Nancy Holroyd (192338)
Alison Morrison (183550)
Andrew Rezansoff (6472268)
Alan Tracey (6472271)
Eileen Devaney (364093)
Matthew Berriman (5353)
Neil Sargison (183538)
James Cotton (27635)
John Gilleard (3400712)

March 2019

Figure S4. Summary of genome-wide change in FST throughout the backcross and subsequent passage. Lin...

Additional file 2: Table S3. of Genome-wide SNP analysis using 2b-RAD sequencing identifies the candidate genes putatively associated with resistance to ivermectin in Haemonchus contortus

Xiaoping Luo (78121)
Xiaona Shi (3661393)
Chunxiu Yuan (124253)
Min Ai (2452732)
Cheng Ge (286997)
Min Hu (41912)
Xingang Feng (124244)
Xiaoye Yang (3661390)

January 2017

Nucleotide sites and SNPs identified on each scaffold of both susceptible and resistant strains of H...

Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus.

Doyle, Stephen R
Illingworth, Christopher
Laing, Roz
Bartley, David J
Redman, Elizabeth
Martinelli, Axel
Holroyd, Nancy
Morrison, Alison A
Rezansoff, Andrew
Tracey, Alan
Devaney, Eileen
Berriman, Matthew
Sargison, Neil
Cotton, James A
Gilleard, John S

March 2019

BACKGROUND: Infections with helminths cause an enormous disease burden in billions of animals and pl...

Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Stephen R. Doyle
Christopher J. R. Illingworth
Roz Laing
David J. Bartley
Elizabeth Redman
Axel Martinelli
Nancy Holroyd
Alison A. Morrison
Andrew Rezansoff
Alan Tracey
Eileen Devaney
Matthew Berriman
Neil Sargison
James A. Cotton
John S. Gilleard

March 2019

Abstract Background Infections with helminths cause an enormous disease burden in billions of animal...

Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Doyle, Stephen R.
Illingworth, Christopher J.R.
Laing, Roz
Bartley, David J.
Redman, Elizabeth
Martinelli, Axel
Holroyd, Nancy
Morrison, Alison A.
Rezansoff, Andrew
Tracey, Alan
Devaney, Eileen
Berriman, Matthew
Sargison, Neil
Cotton, James A.
Gilleard, John S.

March 2019

BACKGROUND:Infections with helminths cause an enormous disease burden in billions of animals and pla...

Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Doyle, Stephen R.
Illingworth, Christopher J.R.
Laing, Roz
Bartley, David J.
Redman, Elizabeth
Martinelli, Axel
Holroyd, Nancy
Morrison, Alison A.
Rezansoff, Andrew
Tracey, Alan
Devaney, Eileen
Berriman, Matthew
Sargison, Neil
Cotton, James A.
Gilleard, John S.

March 2019

BACKGROUND:Infections with helminths cause an enormous disease burden in billions of animals and pla...

Evidence from two independent backcross experiments supports genetic linkage of microsatellite Hcms8a20, but not other candidate loci, to a major ivermectin resistance locus in Haemonchus contortus

Rezansoff, Andrew M.
Laing, Roz
Gilleard, John S.

September 2016

Haemonchus contortus is the leading parasitic nematode species used to study anthelmintic drug resis...

Genome-wide analysis of the response to ivermectin treatment by a Swedish field population of Haemonchus contortus

Baltrusis, Paulius
Doyle, Stephen R.
Halvarsson, Peter
Höglund, Johan

January 2022

Haemonchus contortus is a pathogenic gastrointestinal nematode of small ruminants and, in part due t...

Additional file 10: of Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Stephen Doyle (1420624)
Christopher Illingworth (6472265)
Roz Laing (183493)
David Bartley (3028725)
Elizabeth Redman (183534)
Axel Martinelli (252562)
Nancy Holroyd (192338)
Alison Morrison (183550)
Andrew Rezansoff (6472268)
Alan Tracey (6472271)
Eileen Devaney (364093)
Matthew Berriman (5353)
Neil Sargison (183538)
James Cotton (27635)
John Gilleard (3400712)

March 2019

Figure S8. Contour maps of log likelihood scores derived from the two locus driver model. A. MHco10(...

Additional file 8: of Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Stephen Doyle (1420624)
Christopher Illingworth (6472265)
Roz Laing (183493)
David Bartley (3028725)
Elizabeth Redman (183534)
Axel Martinelli (252562)
Nancy Holroyd (192338)
Alison Morrison (183550)
Andrew Rezansoff (6472268)
Alan Tracey (6472271)
Eileen Devaney (364093)
Matthew Berriman (5353)
Neil Sargison (183538)
James Cotton (27635)
John Gilleard (3400712)

March 2019

Figure S9. Relative position and location of candidate genes from the literature proposed to be asso...

Additional file 2: of Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Stephen Doyle (1420624)
Christopher Illingworth (6472265)
Roz Laing (183493)
David Bartley (3028725)
Elizabeth Redman (183534)
Axel Martinelli (252562)
Nancy Holroyd (192338)
Alison Morrison (183550)
Andrew Rezansoff (6472268)
Alan Tracey (6472271)
Eileen Devaney (364093)
Matthew Berriman (5353)
Neil Sargison (183538)
James Cotton (27635)
John Gilleard (3400712)

March 2019

Figure S2. Distribution of âprivateâ variant sites per parental population. A. MHco3(ISE). B. MH...

Additional file 9: of Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Stephen Doyle (1420624)
Christopher Illingworth (6472265)
Roz Laing (183493)
David Bartley (3028725)
Elizabeth Redman (183534)
Axel Martinelli (252562)
Nancy Holroyd (192338)
Alison Morrison (183550)
Andrew Rezansoff (6472268)
Alan Tracey (6472271)
Eileen Devaney (364093)
Matthew Berriman (5353)
Neil Sargison (183538)
James Cotton (27635)
John Gilleard (3400712)

March 2019

Figure S10. Haplotype structure of chromosome V in an example output from the model under neutral ev...

Additional file 11: of Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Stephen Doyle (1420624)
Christopher Illingworth (6472265)
Roz Laing (183493)
David Bartley (3028725)
Elizabeth Redman (183534)
Axel Martinelli (252562)
Nancy Holroyd (192338)
Alison Morrison (183550)
Andrew Rezansoff (6472268)
Alan Tracey (6472271)
Eileen Devaney (364093)
Matthew Berriman (5353)
Neil Sargison (183538)
James Cotton (27635)
John Gilleard (3400712)

March 2019

Figure S5. Fits between the model and the data for each data sample. Blue dots show filtered allele ...

Additional file 1: of Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Stephen Doyle (1420624)
Christopher Illingworth (6472265)
Roz Laing (183493)
David Bartley (3028725)
Elizabeth Redman (183534)
Axel Martinelli (252562)
Nancy Holroyd (192338)
Alison Morrison (183550)
Andrew Rezansoff (6472268)
Alan Tracey (6472271)
Eileen Devaney (364093)
Matthew Berriman (5353)
Neil Sargison (183538)
James Cotton (27635)
John Gilleard (3400712)

March 2019

Figure S1. Characterisation of within-population diversity. A. Within population nucleotide diversit...

Additional file 5: of Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Stephen Doyle (1420624)
Christopher Illingworth (6472265)
Roz Laing (183493)
David Bartley (3028725)
Elizabeth Redman (183534)
Axel Martinelli (252562)
Nancy Holroyd (192338)
Alison Morrison (183550)
Andrew Rezansoff (6472268)
Alan Tracey (6472271)
Eileen Devaney (364093)
Matthew Berriman (5353)
Neil Sargison (183538)
James Cotton (27635)
John Gilleard (3400712)

March 2019

Figure S6. Location of significantly non-neutral loci identified using the single-locus population g...

Additional file 4: of Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Stephen Doyle (1420624)
Christopher Illingworth (6472265)
Roz Laing (183493)
David Bartley (3028725)
Elizabeth Redman (183534)
Axel Martinelli (252562)
Nancy Holroyd (192338)
Alison Morrison (183550)
Andrew Rezansoff (6472268)
Alan Tracey (6472271)
Eileen Devaney (364093)
Matthew Berriman (5353)
Neil Sargison (183538)
James Cotton (27635)
John Gilleard (3400712)

March 2019

Figure S4. Summary of genome-wide change in FST throughout the backcross and subsequent passage. Lin...

Additional file 2: Table S3. of Genome-wide SNP analysis using 2b-RAD sequencing identifies the candidate genes putatively associated with resistance to ivermectin in Haemonchus contortus

Xiaoping Luo (78121)
Xiaona Shi (3661393)
Chunxiu Yuan (124253)
Min Ai (2452732)
Cheng Ge (286997)
Min Hu (41912)
Xingang Feng (124244)
Xiaoye Yang (3661390)

January 2017

Nucleotide sites and SNPs identified on each scaffold of both susceptible and resistant strains of H...

Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus.

Doyle, Stephen R
Illingworth, Christopher
Laing, Roz
Bartley, David J
Redman, Elizabeth
Martinelli, Axel
Holroyd, Nancy
Morrison, Alison A
Rezansoff, Andrew
Tracey, Alan
Devaney, Eileen
Berriman, Matthew
Sargison, Neil
Cotton, James A
Gilleard, John S

March 2019

BACKGROUND: Infections with helminths cause an enormous disease burden in billions of animals and pl...

Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Stephen R. Doyle
Christopher J. R. Illingworth
Roz Laing
David J. Bartley
Elizabeth Redman
Axel Martinelli
Nancy Holroyd
Alison A. Morrison
Andrew Rezansoff
Alan Tracey
Eileen Devaney
Matthew Berriman
Neil Sargison
James A. Cotton
John S. Gilleard

March 2019

Abstract Background Infections with helminths cause an enormous disease burden in billions of animal...

Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Doyle, Stephen R.
Illingworth, Christopher J.R.
Laing, Roz
Bartley, David J.
Redman, Elizabeth
Martinelli, Axel
Holroyd, Nancy
Morrison, Alison A.
Rezansoff, Andrew
Tracey, Alan
Devaney, Eileen
Berriman, Matthew
Sargison, Neil
Cotton, James A.
Gilleard, John S.

March 2019

BACKGROUND:Infections with helminths cause an enormous disease burden in billions of animals and pla...

Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Doyle, Stephen R.
Illingworth, Christopher J.R.
Laing, Roz
Bartley, David J.
Redman, Elizabeth
Martinelli, Axel
Holroyd, Nancy
Morrison, Alison A.
Rezansoff, Andrew
Tracey, Alan
Devaney, Eileen
Berriman, Matthew
Sargison, Neil
Cotton, James A.
Gilleard, John S.

March 2019

BACKGROUND:Infections with helminths cause an enormous disease burden in billions of animals and pla...

Evidence from two independent backcross experiments supports genetic linkage of microsatellite Hcms8a20, but not other candidate loci, to a major ivermectin resistance locus in Haemonchus contortus

Rezansoff, Andrew M.
Laing, Roz
Gilleard, John S.

September 2016

Haemonchus contortus is the leading parasitic nematode species used to study anthelmintic drug resis...

Genome-wide analysis of the response to ivermectin treatment by a Swedish field population of Haemonchus contortus

Baltrusis, Paulius
Doyle, Stephen R.
Halvarsson, Peter
Höglund, Johan

January 2022

Haemonchus contortus is a pathogenic gastrointestinal nematode of small ruminants and, in part due t...

Additional file 12: of Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Abstract

Extracted data

Additional file 12: of Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

Abstract

Extracted data

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