Additional file 5: of HHLA2 in intrahepatic cholangiocarcinoma: an immune checkpoint with prognostic significance and wider expression compared with PD-L1

Additional file 2: of Transcriptomic analysis and mutational status of IDH1 in paired primary-recurrent intrahepatic cholangiocarcinoma

C. Peraldo-Neia (5343293)
P. Ostano (5343290)
G. Cavalloni (5343251)
Y. Pignochino (5343278)
D. Sangiolo (5343284)
L. De Cecco (5343275)
E. Marchesi (5343248)
D. Ribero (5343266)
A. Scarpa (5343287)
A. De Rose (5343269)
A. Giuliani (491396)
F. Calise (5343263)
C. Raggi (5343260)
P. Invernizzi (5343254)
M. Aglietta (5343272)
G. Chiorino (5343257)
F. Leone (5343281)

June 2018

Figure S1. Representative images of H/E staining of PRs (A and C) and their RECs counterparts (B and...

Additional file 1: Figure S1. of PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma

Guanzhen Yu (781304)
Wenlong Yu (1600288)
Guangzhi Jin (3767215)
Dongyun Xu (3767218)
Ying Chen (9697)
Tian Xia (139140)
Allan Yu (3767221)
Wenzheng Fang (2098036)
Xiaoli Zhang (135098)
Zhaosheng Li (1465150)
Keping Xie (306727)

November 2015

PKM2 expression in HC tissues. A, Western blotting revealed the expression pattern of KK1, PFKB, and...

Additional file 1: of Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma

Joni LeppĂ¤nen (5482406)
Olli Helminen (768250)
Heikki Huhta (768249)
Joonas Kauppila (474918)
Joel Isohookana (5482403)
Kirsi-Maria Haapasaari (5482397)
Seppo Parkkila (41013)
Juha Saarnio (58388)
Petri Lehenkari (123659)
Tuomo Karttunen (58389)

July 2018

Figure S1. Positive and negative controls for HIF-1alpha staining. The HIF-1alpha staining pattern i...

Additional file 4: of HHLA2 in intrahepatic cholangiocarcinoma: an immune checkpoint with prognostic significance and wider expression compared with PD-L1

Chu-Yu Jing (6477710)
Yi-Peng Fu (6477713)
Yong Yi (147488)
Mei-Xia Zhang (6477716)
Su-Su Zheng (422272)
Jin-Long Huang (599641)
Wei Gan (172146)
Xin Xu (11989)
Jia-Jia Lin (6477719)
Juan Zhang (48597)
Shuang-Jian Qiu (157512)
Bo-Heng Zhang (422274)

March 2019

Table S4. Correlation between PD-L1 expression on TC and different immune infiltrates (DOCX 16 kb

Additional file 1: of HHLA2 in intrahepatic cholangiocarcinoma: an immune checkpoint with prognostic significance and wider expression compared with PD-L1

Chu-Yu Jing (6477710)
Yi-Peng Fu (6477713)
Yong Yi (147488)
Mei-Xia Zhang (6477716)
Su-Su Zheng (422272)
Jin-Long Huang (599641)
Wei Gan (172146)
Xin Xu (11989)
Jia-Jia Lin (6477719)
Juan Zhang (48597)
Shuang-Jian Qiu (157512)
Bo-Heng Zhang (422274)

March 2019

Table S1. Correlation between PD-L1 expression and baseline clinicopathological features in ICC (DOC...

Additional file 6: of HHLA2 in intrahepatic cholangiocarcinoma: an immune checkpoint with prognostic significance and wider expression compared with PD-L1

Chu-Yu Jing (6477710)
Yi-Peng Fu (6477713)
Yong Yi (147488)
Mei-Xia Zhang (6477716)
Su-Su Zheng (422272)
Jin-Long Huang (599641)
Wei Gan (172146)
Xin Xu (11989)
Jia-Jia Lin (6477719)
Juan Zhang (48597)
Shuang-Jian Qiu (157512)
Bo-Heng Zhang (422274)

March 2019

Table S6. Univariate analyses of densities of different immune cells for OS and RFS in ICC. (DOCX 17...

Additional file 3: of HHLA2 in intrahepatic cholangiocarcinoma: an immune checkpoint with prognostic significance and wider expression compared with PD-L1

Chu-Yu Jing (6477710)
Yi-Peng Fu (6477713)
Yong Yi (147488)
Mei-Xia Zhang (6477716)
Su-Su Zheng (422272)
Jin-Long Huang (599641)
Wei Gan (172146)
Xin Xu (11989)
Jia-Jia Lin (6477719)
Juan Zhang (48597)
Shuang-Jian Qiu (157512)
Bo-Heng Zhang (422274)

March 2019

Table S3. Correlation between HHLA2 expression and different immune infiltrates (DOCX 16 kb

Additional file 2: of HHLA2 in intrahepatic cholangiocarcinoma: an immune checkpoint with prognostic significance and wider expression compared with PD-L1

Chu-Yu Jing (6477710)
Yi-Peng Fu (6477713)
Yong Yi (147488)
Mei-Xia Zhang (6477716)
Su-Su Zheng (422272)
Jin-Long Huang (599641)
Wei Gan (172146)
Xin Xu (11989)
Jia-Jia Lin (6477719)
Juan Zhang (48597)
Shuang-Jian Qiu (157512)
Bo-Heng Zhang (422274)

March 2019

Table S2. Univariate and multivariate analyses of prognostic factors correlated with RFS (DOCX 16 kb

HHLA2 in intrahepatic cholangiocarcinoma: an immune checkpoint with prognostic significance and wider expression compared with PD-L1

Chu-Yu Jing
Yi-Peng Fu
Yong Yi
Mei-Xia Zhang
Su-Su Zheng
Jin-Long Huang
Wei Gan
Xin Xu
Jia-Jia Lin
Juan Zhang
Shuang-Jian Qiu
Bo-Heng Zhang

March 2019

Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a highly mortal malignancy with limited...

Additional file 1: of Programmed cell death ligand 1 (PD-L1, CD274) in cholangiocarcinoma – correlation with clinicopathological data and comparison of antibodies

Mark Kriegsmann (3485276)
Stephanie Roessler (479270)
Katharina Kriegsmann (6210830)
Marcus Renner (3097578)
Rémi Longuespée (3858949)
Thomas Albrecht (361635)
Moritz Loeffler (6210842)
Stephan Singer (3404138)
Arianeb Mehrabi (3097584)
Monika Vogel (6210848)
Anita Pathil (3097575)
Bruno Köhler (6210851)
Christoph Springfeld (6210854)
Christian Rupp (188332)
Karl Weiss (471420)
Benjamin Goeppert (539472)

January 2019

Figure S1. Example of a typical staining pattern of on-slide control tissues (PD-L1, SP263). Tonsill...

Additional file 5 of Overexpression of POLA2 in hepatocellular carcinoma is involved in immune infiltration and predicts a poor prognosis

Long Liu (390523)
Qi Wang (22418)
Linjun Wu (14680456)
Lele Zhang (388913)
Yuxi Huang (14160785)
Haihua Yang (728858)
Le guo (16550040)
Zheping Fang (16550043)
Xuequan Wang (697301)

July 2023

Additional Figure S4: Immune cell type expression analysis results of POLA2 based on HPA, Monaco, an...

Additional file 2: of VISTA expression associated with CD8 confers a favorable immune microenvironment and better overall survival in hepatocellular carcinoma

Ming Zhang (9736)
Hua-Jin Pang (5167337)
Wei Zhao (14321)
Yu-Fa Li (5167340)
Li-Xu Yan (223343)
Zhong-Yi Dong (5167343)
Xiao-Feng He (456180)

May 2018

Figure S1. Immunohistochemically staining of PD-L1 proteins in patients with hepatocellular carcinom...

Additional file 2 of Overexpression of POLA2 in hepatocellular carcinoma is involved in immune infiltration and predicts a poor prognosis

Long Liu (390523)
Qi Wang (22418)
Linjun Wu (14680456)
Lele Zhang (388913)
Yuxi Huang (14160785)
Haihua Yang (728858)
Le guo (16550040)
Zheping Fang (16550043)
Xuequan Wang (697301)

July 2023

Additional Figure S1: The high expression of POLA1 and POLA2 in hepatocellular carcinoma analyzed by...

Additional file 2: Table S1. of PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma

Guanzhen Yu (781304)
Wenlong Yu (1600288)
Guangzhi Jin (3767215)
Dongyun Xu (3767218)
Ying Chen (9697)
Tian Xia (139140)
Allan Yu (3767221)
Wenzheng Fang (2098036)
Xiaoli Zhang (135098)
Zhaosheng Li (1465150)
Keping Xie (306727)

November 2015

Association between expression of PKM2, PFKB, and HK1 and clinical variables in HC patients. Table S...

Additional file 3 of Overexpression of POLA2 in hepatocellular carcinoma is involved in immune infiltration and predicts a poor prognosis

Long Liu (390523)
Qi Wang (22418)
Linjun Wu (14680456)
Lele Zhang (388913)
Yuxi Huang (14160785)
Haihua Yang (728858)
Le guo (16550040)
Zheping Fang (16550043)
Xuequan Wang (697301)

July 2023

Additional Figure S2: (A) Co-expression analysis of POLA1 and POLA2; (B) ROC diagnostic curve of POL...

Additional file 2: of Transcriptomic analysis and mutational status of IDH1 in paired primary-recurrent intrahepatic cholangiocarcinoma

C. Peraldo-Neia (5343293)
P. Ostano (5343290)
G. Cavalloni (5343251)
Y. Pignochino (5343278)
D. Sangiolo (5343284)
L. De Cecco (5343275)
E. Marchesi (5343248)
D. Ribero (5343266)
A. Scarpa (5343287)
A. De Rose (5343269)
A. Giuliani (491396)
F. Calise (5343263)
C. Raggi (5343260)
P. Invernizzi (5343254)
M. Aglietta (5343272)
G. Chiorino (5343257)
F. Leone (5343281)

June 2018

Figure S1. Representative images of H/E staining of PRs (A and C) and their RECs counterparts (B and...

Additional file 1: Figure S1. of PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma

Guanzhen Yu (781304)
Wenlong Yu (1600288)
Guangzhi Jin (3767215)
Dongyun Xu (3767218)
Ying Chen (9697)
Tian Xia (139140)
Allan Yu (3767221)
Wenzheng Fang (2098036)
Xiaoli Zhang (135098)
Zhaosheng Li (1465150)
Keping Xie (306727)

November 2015

PKM2 expression in HC tissues. A, Western blotting revealed the expression pattern of KK1, PFKB, and...

Additional file 1: of Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma

Joni LeppĂ¤nen (5482406)
Olli Helminen (768250)
Heikki Huhta (768249)
Joonas Kauppila (474918)
Joel Isohookana (5482403)
Kirsi-Maria Haapasaari (5482397)
Seppo Parkkila (41013)
Juha Saarnio (58388)
Petri Lehenkari (123659)
Tuomo Karttunen (58389)

July 2018

Figure S1. Positive and negative controls for HIF-1alpha staining. The HIF-1alpha staining pattern i...

Additional file 4: of HHLA2 in intrahepatic cholangiocarcinoma: an immune checkpoint with prognostic significance and wider expression compared with PD-L1

Chu-Yu Jing (6477710)
Yi-Peng Fu (6477713)
Yong Yi (147488)
Mei-Xia Zhang (6477716)
Su-Su Zheng (422272)
Jin-Long Huang (599641)
Wei Gan (172146)
Xin Xu (11989)
Jia-Jia Lin (6477719)
Juan Zhang (48597)
Shuang-Jian Qiu (157512)
Bo-Heng Zhang (422274)

March 2019

Table S4. Correlation between PD-L1 expression on TC and different immune infiltrates (DOCX 16 kb

Additional file 1: of HHLA2 in intrahepatic cholangiocarcinoma: an immune checkpoint with prognostic significance and wider expression compared with PD-L1

Chu-Yu Jing (6477710)
Yi-Peng Fu (6477713)
Yong Yi (147488)
Mei-Xia Zhang (6477716)
Su-Su Zheng (422272)
Jin-Long Huang (599641)
Wei Gan (172146)
Xin Xu (11989)
Jia-Jia Lin (6477719)
Juan Zhang (48597)
Shuang-Jian Qiu (157512)
Bo-Heng Zhang (422274)

March 2019

Table S1. Correlation between PD-L1 expression and baseline clinicopathological features in ICC (DOC...

Additional file 6: of HHLA2 in intrahepatic cholangiocarcinoma: an immune checkpoint with prognostic significance and wider expression compared with PD-L1

Chu-Yu Jing (6477710)
Yi-Peng Fu (6477713)
Yong Yi (147488)
Mei-Xia Zhang (6477716)
Su-Su Zheng (422272)
Jin-Long Huang (599641)
Wei Gan (172146)
Xin Xu (11989)
Jia-Jia Lin (6477719)
Juan Zhang (48597)
Shuang-Jian Qiu (157512)
Bo-Heng Zhang (422274)

March 2019

Table S6. Univariate analyses of densities of different immune cells for OS and RFS in ICC. (DOCX 17...

Additional file 3: of HHLA2 in intrahepatic cholangiocarcinoma: an immune checkpoint with prognostic significance and wider expression compared with PD-L1

Chu-Yu Jing (6477710)
Yi-Peng Fu (6477713)
Yong Yi (147488)
Mei-Xia Zhang (6477716)
Su-Su Zheng (422272)
Jin-Long Huang (599641)
Wei Gan (172146)
Xin Xu (11989)
Jia-Jia Lin (6477719)
Juan Zhang (48597)
Shuang-Jian Qiu (157512)
Bo-Heng Zhang (422274)

March 2019

Table S3. Correlation between HHLA2 expression and different immune infiltrates (DOCX 16 kb

Additional file 2: of HHLA2 in intrahepatic cholangiocarcinoma: an immune checkpoint with prognostic significance and wider expression compared with PD-L1

Chu-Yu Jing (6477710)
Yi-Peng Fu (6477713)
Yong Yi (147488)
Mei-Xia Zhang (6477716)
Su-Su Zheng (422272)
Jin-Long Huang (599641)
Wei Gan (172146)
Xin Xu (11989)
Jia-Jia Lin (6477719)
Juan Zhang (48597)
Shuang-Jian Qiu (157512)
Bo-Heng Zhang (422274)

March 2019

Table S2. Univariate and multivariate analyses of prognostic factors correlated with RFS (DOCX 16 kb

HHLA2 in intrahepatic cholangiocarcinoma: an immune checkpoint with prognostic significance and wider expression compared with PD-L1

Chu-Yu Jing
Yi-Peng Fu
Yong Yi
Mei-Xia Zhang
Su-Su Zheng
Jin-Long Huang
Wei Gan
Xin Xu
Jia-Jia Lin
Juan Zhang
Shuang-Jian Qiu
Bo-Heng Zhang

March 2019

Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a highly mortal malignancy with limited...

Additional file 1: of Programmed cell death ligand 1 (PD-L1, CD274) in cholangiocarcinoma – correlation with clinicopathological data and comparison of antibodies

Mark Kriegsmann (3485276)
Stephanie Roessler (479270)
Katharina Kriegsmann (6210830)
Marcus Renner (3097578)
Rémi Longuespée (3858949)
Thomas Albrecht (361635)
Moritz Loeffler (6210842)
Stephan Singer (3404138)
Arianeb Mehrabi (3097584)
Monika Vogel (6210848)
Anita Pathil (3097575)
Bruno Köhler (6210851)
Christoph Springfeld (6210854)
Christian Rupp (188332)
Karl Weiss (471420)
Benjamin Goeppert (539472)

January 2019

Figure S1. Example of a typical staining pattern of on-slide control tissues (PD-L1, SP263). Tonsill...

Additional file 5 of Overexpression of POLA2 in hepatocellular carcinoma is involved in immune infiltration and predicts a poor prognosis

Long Liu (390523)
Qi Wang (22418)
Linjun Wu (14680456)
Lele Zhang (388913)
Yuxi Huang (14160785)
Haihua Yang (728858)
Le guo (16550040)
Zheping Fang (16550043)
Xuequan Wang (697301)

July 2023

Additional Figure S4: Immune cell type expression analysis results of POLA2 based on HPA, Monaco, an...

Additional file 2: of VISTA expression associated with CD8 confers a favorable immune microenvironment and better overall survival in hepatocellular carcinoma

Ming Zhang (9736)
Hua-Jin Pang (5167337)
Wei Zhao (14321)
Yu-Fa Li (5167340)
Li-Xu Yan (223343)
Zhong-Yi Dong (5167343)
Xiao-Feng He (456180)

May 2018

Figure S1. Immunohistochemically staining of PD-L1 proteins in patients with hepatocellular carcinom...

Additional file 2 of Overexpression of POLA2 in hepatocellular carcinoma is involved in immune infiltration and predicts a poor prognosis

Long Liu (390523)
Qi Wang (22418)
Linjun Wu (14680456)
Lele Zhang (388913)
Yuxi Huang (14160785)
Haihua Yang (728858)
Le guo (16550040)
Zheping Fang (16550043)
Xuequan Wang (697301)

July 2023

Additional Figure S1: The high expression of POLA1 and POLA2 in hepatocellular carcinoma analyzed by...

Additional file 2: Table S1. of PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma

Guanzhen Yu (781304)
Wenlong Yu (1600288)
Guangzhi Jin (3767215)
Dongyun Xu (3767218)
Ying Chen (9697)
Tian Xia (139140)
Allan Yu (3767221)
Wenzheng Fang (2098036)
Xiaoli Zhang (135098)
Zhaosheng Li (1465150)
Keping Xie (306727)

November 2015

Association between expression of PKM2, PFKB, and HK1 and clinical variables in HC patients. Table S...

Additional file 3 of Overexpression of POLA2 in hepatocellular carcinoma is involved in immune infiltration and predicts a poor prognosis

Long Liu (390523)
Qi Wang (22418)
Linjun Wu (14680456)
Lele Zhang (388913)
Yuxi Huang (14160785)
Haihua Yang (728858)
Le guo (16550040)
Zheping Fang (16550043)
Xuequan Wang (697301)

July 2023

Additional Figure S2: (A) Co-expression analysis of POLA1 and POLA2; (B) ROC diagnostic curve of POL...

Additional file 2: of Transcriptomic analysis and mutational status of IDH1 in paired primary-recurrent intrahepatic cholangiocarcinoma

C. Peraldo-Neia (5343293)
P. Ostano (5343290)
G. Cavalloni (5343251)
Y. Pignochino (5343278)
D. Sangiolo (5343284)
L. De Cecco (5343275)
E. Marchesi (5343248)
D. Ribero (5343266)
A. Scarpa (5343287)
A. De Rose (5343269)
A. Giuliani (491396)
F. Calise (5343263)
C. Raggi (5343260)
P. Invernizzi (5343254)
M. Aglietta (5343272)
G. Chiorino (5343257)
F. Leone (5343281)

June 2018

Figure S1. Representative images of H/E staining of PRs (A and C) and their RECs counterparts (B and...

Additional file 1: Figure S1. of PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma

Guanzhen Yu (781304)
Wenlong Yu (1600288)
Guangzhi Jin (3767215)
Dongyun Xu (3767218)
Ying Chen (9697)
Tian Xia (139140)
Allan Yu (3767221)
Wenzheng Fang (2098036)
Xiaoli Zhang (135098)
Zhaosheng Li (1465150)
Keping Xie (306727)

November 2015

PKM2 expression in HC tissues. A, Western blotting revealed the expression pattern of KK1, PFKB, and...

Additional file 1: of Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma

Joni LeppĂ¤nen (5482406)
Olli Helminen (768250)
Heikki Huhta (768249)
Joonas Kauppila (474918)
Joel Isohookana (5482403)
Kirsi-Maria Haapasaari (5482397)
Seppo Parkkila (41013)
Juha Saarnio (58388)
Petri Lehenkari (123659)
Tuomo Karttunen (58389)

July 2018

Figure S1. Positive and negative controls for HIF-1alpha staining. The HIF-1alpha staining pattern i...

Additional file 5: of HHLA2 in intrahepatic cholangiocarcinoma: an immune checkpoint with prognostic significance and wider expression compared with PD-L1

Abstract

Extracted data

Additional file 5: of HHLA2 in intrahepatic cholangiocarcinoma: an immune checkpoint with prognostic significance and wider expression compared with PD-L1

Abstract

Extracted data

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