Diastereoselective Synthesis of CF<sub>3</sub>‑Substituted Spiroisochromans by [1,5]-Hydride Shift/Cyclization/Intramolecular Friedel–Crafts Reaction Sequence
- Risa Tamura (5183828)
- Eriko Kitamura (6474701)
- Ryosuke Tsutsumi (1657732)
- Masahiro Yamanaka (1391734)
- Takahiko Akiyama (1669018)
- Keiji Mori (1835440)
Publication date
March 2019
DOI Publisher
American Chemical Society (ACS)Abstract
Developed herein is a diastereoselective synthesis of CF3-substituted spiroisochromans via C(sp3)–H bond functionalization involving sequential transformations ([1,5]-hydride shift/cyclization/elimination of MeOH/intramolecular Friedel–Crafts reaction)
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