Generation and validation of a CCR2-Cre mouse.

(A) Schematic of the modification of a BAC containing the endogenous CCR2 locus in order to insert the Cre recombinase gene, a stop codon, and a frameshift mutation downstream of the CCR2 promoter. (B) Representative flow plots and histograms of tdRFP expression by IM in the bone marrow, blood and lung of naive CCR2-Cre Rosa26flSTOP-tdRFP mice. The dotted lines in the histograms represent naive Rosa26flSTOP-tdRFP control mice.