Expanding the watch list for potential Ebola virus antibody escape mutations - Fig 1

(A) Structure of EBOV GP trimer in complex with the Ab100 antibody. GP1 is gray, GP2 is red and the heavy and the light chains of Ab100 are brown. (B) & (C) Mutations in the GP complex with ΔΔGBind > 2 kcal/mol (i.e., above black dashed line) are considered disruptive and are highlighted using green stick representation. (D) ΔΔGBind values (gray circles) for all 19 possible mutations at each site of GP1 (33–278) and GP2 (502–599). Different colors and counts in the legend indicate locations and number of mutations with ΔΔGBind > 2 kcal/mol on the GP complex.