Immunohistochemical staining showing the expression of phosphorylated p38 in the mouse renal tubulointerstitial area after UUO and administration of p38 MAPK inhibitor.

Scale bar = 50 μm (original magnification x300). (A) Sham-operated group. (B) UUO-operated group administered 20% DMSO vehicle. (C) UUO-operated group administered 5 mg/kg/day p38 MAPK inhibitor. (D) UUO-operated group administered 10 mg/kg/day p38 MAPK inhibitor. Tubulointerstitial expression of phosphorylated p38 decreased significantly in the groups treated with p38 MAPK inhibitor. UUO, unilateral ureteral obstruction.