Different strategies for treatment and prevention of Alzheimer’s disease (AD) are currently under investigation, including passive immunization with anti-amyloid β (anti-Aβ) monoclonal antibodies (mAbs). Here, we investigate the therapeutic potential of a novel type of Aβ-targeting agent based on an affibody molecule with fundamentally different properties to mAbs. We generated a therapeutic candidate, denoted ZSYM73-albumin-binding domain (ABD; 16.8 kDa), by genetic linkage of the dimeric ZSYM73 affibody for sequestering of monomeric Aβ-peptides and an ABD for extension of its in vivo half-life. Amyloid precursor protein (APP)/PS1 transgenic AD mice were administered with ZSYM73-ABD, followed by behavioral examination and immunohistochemis...
No disease-modifying compounds are available to halt disease progression in Alzheimer’s disease (A...
Alzheimer's disease (AD) is the most common form of dementia in the elderly. AD is characterized by ...
Passive immunotherapy is a very promising approach for the treatment of Alzheimer’s disease (AD). Am...
Different strategies for treatment and prevention of Alzheimer’s disease (AD) are currently under in...
Different strategies for treatment and prevention of Alzheimer’s disease (AD) are currently under in...
Different strategies for treatment and prevention of Alzheimer’s disease (AD) are currently under in...
Different strategies for treatment and prevention of Alzheimer’s disease (AD) are currently under in...
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is associated with the agg...
Alzheimer’s disease results from an accumulation of aggregated amyloid beta peptide into oligomeric ...
Aggregation of the amyloid-β peptide (Aβ) is one of the main pathological hallmarks in Alzheimer’s d...
Abstract Background Oligomeric forms of amyloid-β (Aβ) and tau are increasing being recognized as ke...
Many neurodegenerative diseases are characterized by the conformational change of normal self-protei...
Abstract Background Anti-amyloid β (Aβ) immunotherapy represents a major area of drug development fo...
AbstractAlzheimer's disease (AD) is one of the categories of neurodegenerative diseases characterize...
Alzheimer’s disease (AD) is the leading form of dementia affecting approximately 35 million people w...
No disease-modifying compounds are available to halt disease progression in Alzheimer’s disease (A...
Alzheimer's disease (AD) is the most common form of dementia in the elderly. AD is characterized by ...
Passive immunotherapy is a very promising approach for the treatment of Alzheimer’s disease (AD). Am...
Different strategies for treatment and prevention of Alzheimer’s disease (AD) are currently under in...
Different strategies for treatment and prevention of Alzheimer’s disease (AD) are currently under in...
Different strategies for treatment and prevention of Alzheimer’s disease (AD) are currently under in...
Different strategies for treatment and prevention of Alzheimer’s disease (AD) are currently under in...
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is associated with the agg...
Alzheimer’s disease results from an accumulation of aggregated amyloid beta peptide into oligomeric ...
Aggregation of the amyloid-β peptide (Aβ) is one of the main pathological hallmarks in Alzheimer’s d...
Abstract Background Oligomeric forms of amyloid-β (Aβ) and tau are increasing being recognized as ke...
Many neurodegenerative diseases are characterized by the conformational change of normal self-protei...
Abstract Background Anti-amyloid β (Aβ) immunotherapy represents a major area of drug development fo...
AbstractAlzheimer's disease (AD) is one of the categories of neurodegenerative diseases characterize...
Alzheimer’s disease (AD) is the leading form of dementia affecting approximately 35 million people w...
No disease-modifying compounds are available to halt disease progression in Alzheimer’s disease (A...
Alzheimer's disease (AD) is the most common form of dementia in the elderly. AD is characterized by ...
Passive immunotherapy is a very promising approach for the treatment of Alzheimer’s disease (AD). Am...