Analysis of the size and shape of DHA-αSOs (left species) and HNE-αSOs (right species). (A and B): Size distribution of TEM species. Insert: TEM image, scale bar is 30 nm. (C and D): Size distribution of AFM images. Insert: AFM image with height scale. (E and F): Size distribution of DLS species.</p
Superdex 200 purification of (A) DHA-αSOs and (B) HNE-αSOs after 24h incubation. Stability of (C) DH...
<p>(<b>A</b>) The fibrillation kinetics of α-synuclein was monitored with ThT binding fluorescence f...
Monomeric α-synuclein (αSN) species are abundant in nerve terminals where they are hypothesized to p...
Binding of (A) DHA-αSOs and (B) HNE-αSOs to primary hippocampal neurons. Top: DIV 21 rat hippocampal...
3 different scenarios for oligomer-specific biological effects: (A) Specificity: conformational epit...
<p>. AFM image of α-synuclein pre-incubated at 37°C for 7 days. <b>B</b>. Fibrillar aggregates of α-...
Pre-fibrillar oligomers of \u3b1-synuclein are thought to be pathogenic molecules leading to neuroto...
<p>(A, B) Representative FECs of a dimer show unfolding of stable structures with a wide range of si...
Parkinson's Disease (PD) is a neurodegenerative disease for which there currently is no cure. Aggreg...
The synucleinopathies are progressive, neurodegenerative diseases of aging characterized by the accu...
Parkinson’s disease (PD) is the most common neurodegenerative disease and is characterized by the lo...
Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy are disorders featuring a...
Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar neuronal inclusi...
<p>(A, B) Representative FECs of a tetramer reveal many structures with different sizes and unfoldin...
Small oligomers of the protein α-synuclein (αS) are highly cytotoxic species associated with Parkins...
Superdex 200 purification of (A) DHA-αSOs and (B) HNE-αSOs after 24h incubation. Stability of (C) DH...
<p>(<b>A</b>) The fibrillation kinetics of α-synuclein was monitored with ThT binding fluorescence f...
Monomeric α-synuclein (αSN) species are abundant in nerve terminals where they are hypothesized to p...
Binding of (A) DHA-αSOs and (B) HNE-αSOs to primary hippocampal neurons. Top: DIV 21 rat hippocampal...
3 different scenarios for oligomer-specific biological effects: (A) Specificity: conformational epit...
<p>. AFM image of α-synuclein pre-incubated at 37°C for 7 days. <b>B</b>. Fibrillar aggregates of α-...
Pre-fibrillar oligomers of \u3b1-synuclein are thought to be pathogenic molecules leading to neuroto...
<p>(A, B) Representative FECs of a dimer show unfolding of stable structures with a wide range of si...
Parkinson's Disease (PD) is a neurodegenerative disease for which there currently is no cure. Aggreg...
The synucleinopathies are progressive, neurodegenerative diseases of aging characterized by the accu...
Parkinson’s disease (PD) is the most common neurodegenerative disease and is characterized by the lo...
Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy are disorders featuring a...
Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar neuronal inclusi...
<p>(A, B) Representative FECs of a tetramer reveal many structures with different sizes and unfoldin...
Small oligomers of the protein α-synuclein (αS) are highly cytotoxic species associated with Parkins...
Superdex 200 purification of (A) DHA-αSOs and (B) HNE-αSOs after 24h incubation. Stability of (C) DH...
<p>(<b>A</b>) The fibrillation kinetics of α-synuclein was monitored with ThT binding fluorescence f...
Monomeric α-synuclein (αSN) species are abundant in nerve terminals where they are hypothesized to p...