Prediction of the laminar origin of connections for the human cortex.

(A) Cortical regions of the human cortex based on the Desikan-Killiany atlas [48]. Cortical regions are assigned to cortical areas S2 Table for which quantitative cell density measurements are available from the classic cytoarchitectonic map of von Economo and Koskinas [37]. The cell density of each region is the average cell density of the assigned cortical areas. (B) A cytoarchitecture-based model that was built with macaque monkey data was used to predict quantitative laminar origin values (NSG%) of putative connections in the human cortex. Such information cannot be obtained with current in vivo techniques but is essential for addressing structure–function relations in the human cortex, such as relating laminar origin of connections to interareal functional communication in different frequency channels [47]. Area-to-area NSG% predictions are not symmetric and are depicted for all pairs of areas, irrespective of the evidence for the existence of a connection in between them. C, caudal; D, dorsal; max, maximum; min, minimum; NSG%, percentage of supragranular labeled neurons; R, rostral; V, ventral.