Ronald Breslow was one of the leading organic chemists of his generation. He had received the perfect start in gaining a Harvard doctorate at the age of 24 supervised by the legendary Bob Woodward, followed by a year of postdoctoral work in Cambridge with the equally legendary, but scientifically distinct, Alexander Todd. An academic career of 62 years at Columbia University followed, starting in 1955, and scientific success arose quickly. He was a physical organic chemist, using this discipline as a vehicle for tackling all manner of scientific problems and venturing as needed into biology, physics or medicine. He prepared the simplest aromatic species, solved the mechanism of action of Vitamin B1, built bridges between organic chemistry a...