N-251 selectively exhibits leishmanicidal activity against L. donovani D10 intracellular amastigotes.

Trypanocidal and leishmanicidal activities of cytochalasins A–D against intracellular T. cruzi Tulahuen LacZ and L. infantum amastigotes and cytotoxicity for fibroblasts (HFF-1), human macrophages (THP-1) and hepatocytes (HepG2).

Marilia Valli (6091874)
Julia Medeiros Souza (13899274)
Rafael Consolin Chelucci (10178764)
Carolina Rabal Biasetto (13899277)
Angela Regina Araujo (2188726)
Vanderlan da Silva Bolzani (1760392)
Adriano Defini Andricopulo (3133146)

October 2022

Trypanocidal and leishmanicidal activities of cytochalasins A–D against intracellular T. cruzi Tulah...

Development and validation of a novel Leishmania donovani screening cascade for high-throughput screening using a novel axenic assay with high predictivity of Leishmanicidal intracellular activity

Nühs, Andrea
De Rycker, Manu
Manthri, Sujatha
Comer, Eamon
Scherer, Christina A.
Schreiber, Stuart L.
Ioset, Jean-Robert
Gray, David W.

September 2015

Visceral leishmaniasis is an important parasitic disease of the developing world with a limited arse...

Identification of sialic acids on Leishmania donovani amastigotes

Chava, A. K.
Chatterjee, M.
Gerwig, G. J.
Kamerling, J. P.
Mandal, C.

January 2004

The presence of Neu5Ac on promastigotes of Leishmania donovani, the causative organism of Indian vis...

N-251 exhibits leishmanicidal activity against different L. donovani complex parasites.

Kofi Dadzie Kwofie (6503720)
Kai Sato (5314682)
Chizu Sanjoba (768281)
Akina Hino (650213)
Rieko Shimogawara (6503723)
Michael Amoa-Bosompem (6503726)
Irene Ayi (166441)
Daniel A. Boakye (90294)
Abraham K. Anang (6503729)
Kyung-Soo Chang (6503732)
Mitsuko Ohashi (6111626)
Hye-Sook Kim (452255)
Nobuo Ohta (143290)
Yoshitsugu Matsumoto (571082)
Shiroh Iwanaga (121019)

March 2019

N-251 exhibits leishmanicidal activity against different L. donovani complex parasites.</p

Inhibition of intracellular amastigotes by N-251.

Kofi Dadzie Kwofie (6503720)
Kai Sato (5314682)
Chizu Sanjoba (768281)
Akina Hino (650213)
Rieko Shimogawara (6503723)
Michael Amoa-Bosompem (6503726)
Irene Ayi (166441)
Daniel A. Boakye (90294)
Abraham K. Anang (6503729)
Kyung-Soo Chang (6503732)
Mitsuko Ohashi (6111626)
Hye-Sook Kim (452255)
Nobuo Ohta (143290)
Yoshitsugu Matsumoto (571082)
Shiroh Iwanaga (121019)

March 2019

Representative Giemsa-stained images (Bar- 20 μm) showing the leishmanicidal effect of N-251 on L. d...

Oral activity of the antimalarial endoperoxide 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) against Leishmania donovani complex

Kofi Dadzie Kwofie (6503720)
Kai Sato (5314682)
Chizu Sanjoba (768281)
Akina Hino (650213)
Rieko Shimogawara (6503723)
Michael Amoa-Bosompem (6503726)
Irene Ayi (166441)
Daniel A. Boakye (90294)
Abraham K. Anang (6503729)
Kyung-Soo Chang (6503732)
Mitsuko Ohashi (6111626)
Hye-Sook Kim (452255)
Nobuo Ohta (143290)
Yoshitsugu Matsumoto (571082)
Shiroh Iwanaga (121019)

March 2019

Visceral leishmaniasis (VL) is a major problem worldwide and causes significant morbidity and mortal...

Oral activity of the antimalarial endoperoxide 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) against Leishmania donovani complex.

Kofi Dadzie Kwofie
Kai Sato
Chizu Sanjoba
Akina Hino
Rieko Shimogawara
Michael Amoa-Bosompem
Irene Ayi
Daniel A Boakye
Abraham K Anang
Kyung-Soo Chang
Mitsuko Ohashi
Hye-Sook Kim
Nobuo Ohta
Yoshitsugu Matsumoto
Shiroh Iwanaga

March 2019

Visceral leishmaniasis (VL) is a major problem worldwide and causes significant morbidity and mortal...

Anti-leishmanial activity and selectivity indexes of phenolic compounds on amastigotes.

Christine Achiaa Antwi (6397193)
Cynthia Mmalebna Amisigo (6397196)
Jonathan Partt Adjimani (6397199)
Theresa Manful Gwira (4459087)

March 2019

Anti-leishmanial activity and selectivity indexes of phenolic compounds on amastigotes.</p

In vitro activity against L. donovani in IC50 (μM) of compounds fulfilling hit criteria.

Marcel Kaiser (41510)
Pascal Mäser (87895)
Leela Pavan Tadoori (782938)
Jean-Robert Ioset (115415)
Reto Brun (41511)

August 2015

aL. don. axen.: axenic amastigotes of L. donovani, ...

Journal ojAntimicrobial Chemotherapy (1984) 14,463^475 An in-vitro system for determining the activity of compounds against the intracellular amastigote form of Leishmania donovani

R. A. Neal
S. L. Croft

August 2016

A method has been defined for infecting primary mouse peritoneal macrophages with amastigotes of Lei...

and

H. Abdala
N. Alvarez
F. Delmas
C. Di Giorgio
J. M. Robert
G. Le Baut
P. Le Pape

August 2014

Leishmania mexicana promastigote and intracellular amastigote growths were inhibited by the water-so...

Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity

Nühs, Andrea
De Rycker, Manu
Manthri, Sujatha
Comer, Eamon
Scherer, Christina A.
Schreiber, Stuart L.
Ioset, Jean-Robert
Gray, David Michael

February 2017

Visceral leishmaniasis is an important parasitic disease of the developing world with a limited arse...

Using a non-image-based medium-throughput assay for screening compounds targeting n-myristoylation in intracellular leishmania amastigotes

Paape, Daniel
Bell, Andrew S.
Heal, William P.
Hutton, Jennie A.
Leatherbarrow, Robin J.
Tate, Edward W.
Smith, Deborah F.

January 2014

We have refined a medium-throughput assay to screen hit compounds for activity against N-myristoylat...

Amastigotes: Application to Anti-leishmanial Drug Discovery

Aulner Nathalie
Danckaert Anne
Rouault-Hardoin Eline
Desrivot Julie
Helynck Olivier
Commere Pierre-Henri
Munier-Lehmann Hélène
Späth Gerald F.
Shorte Spencer L.
Milon Geneviève
Prina Eric

April 2013

amastigotes that develop and proliferate inside macrophages, thereby causing the pathology of leish...

Using a Non-Image-Based Medium-Throughput Assay for Screening Compounds Targeting N-myristoylation in Intracellular Leishmania Amastigotes

Paape, Daniel
Bell, Andrew S
Heal, William P
Hutton, Jennie A
Leatherbarrow, Robin J
Tate, Edward W
Smith, Deborah F

December 2014

We have refined a medium-throughput assay to screen hit compounds for activity against N-myristoylat...

Trypanocidal and leishmanicidal activities of cytochalasins A–D against intracellular T. cruzi Tulahuen LacZ and L. infantum amastigotes and cytotoxicity for fibroblasts (HFF-1), human macrophages (THP-1) and hepatocytes (HepG2).

Marilia Valli (6091874)
Julia Medeiros Souza (13899274)
Rafael Consolin Chelucci (10178764)
Carolina Rabal Biasetto (13899277)
Angela Regina Araujo (2188726)
Vanderlan da Silva Bolzani (1760392)
Adriano Defini Andricopulo (3133146)

October 2022

Trypanocidal and leishmanicidal activities of cytochalasins A–D against intracellular T. cruzi Tulah...

Development and validation of a novel Leishmania donovani screening cascade for high-throughput screening using a novel axenic assay with high predictivity of Leishmanicidal intracellular activity

Nühs, Andrea
De Rycker, Manu
Manthri, Sujatha
Comer, Eamon
Scherer, Christina A.
Schreiber, Stuart L.
Ioset, Jean-Robert
Gray, David W.

September 2015

Visceral leishmaniasis is an important parasitic disease of the developing world with a limited arse...

Identification of sialic acids on Leishmania donovani amastigotes

Chava, A. K.
Chatterjee, M.
Gerwig, G. J.
Kamerling, J. P.
Mandal, C.

January 2004

The presence of Neu5Ac on promastigotes of Leishmania donovani, the causative organism of Indian vis...

N-251 exhibits leishmanicidal activity against different L. donovani complex parasites.

Kofi Dadzie Kwofie (6503720)
Kai Sato (5314682)
Chizu Sanjoba (768281)
Akina Hino (650213)
Rieko Shimogawara (6503723)
Michael Amoa-Bosompem (6503726)
Irene Ayi (166441)
Daniel A. Boakye (90294)
Abraham K. Anang (6503729)
Kyung-Soo Chang (6503732)
Mitsuko Ohashi (6111626)
Hye-Sook Kim (452255)
Nobuo Ohta (143290)
Yoshitsugu Matsumoto (571082)
Shiroh Iwanaga (121019)

March 2019

N-251 exhibits leishmanicidal activity against different L. donovani complex parasites.</p

Inhibition of intracellular amastigotes by N-251.

Kofi Dadzie Kwofie (6503720)
Kai Sato (5314682)
Chizu Sanjoba (768281)
Akina Hino (650213)
Rieko Shimogawara (6503723)
Michael Amoa-Bosompem (6503726)
Irene Ayi (166441)
Daniel A. Boakye (90294)
Abraham K. Anang (6503729)
Kyung-Soo Chang (6503732)
Mitsuko Ohashi (6111626)
Hye-Sook Kim (452255)
Nobuo Ohta (143290)
Yoshitsugu Matsumoto (571082)
Shiroh Iwanaga (121019)

March 2019

Representative Giemsa-stained images (Bar- 20 μm) showing the leishmanicidal effect of N-251 on L. d...

Oral activity of the antimalarial endoperoxide 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) against Leishmania donovani complex

Kofi Dadzie Kwofie (6503720)
Kai Sato (5314682)
Chizu Sanjoba (768281)
Akina Hino (650213)
Rieko Shimogawara (6503723)
Michael Amoa-Bosompem (6503726)
Irene Ayi (166441)
Daniel A. Boakye (90294)
Abraham K. Anang (6503729)
Kyung-Soo Chang (6503732)
Mitsuko Ohashi (6111626)
Hye-Sook Kim (452255)
Nobuo Ohta (143290)
Yoshitsugu Matsumoto (571082)
Shiroh Iwanaga (121019)

March 2019

Visceral leishmaniasis (VL) is a major problem worldwide and causes significant morbidity and mortal...

Oral activity of the antimalarial endoperoxide 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) against Leishmania donovani complex.

Kofi Dadzie Kwofie
Kai Sato
Chizu Sanjoba
Akina Hino
Rieko Shimogawara
Michael Amoa-Bosompem
Irene Ayi
Daniel A Boakye
Abraham K Anang
Kyung-Soo Chang
Mitsuko Ohashi
Hye-Sook Kim
Nobuo Ohta
Yoshitsugu Matsumoto
Shiroh Iwanaga

March 2019

Visceral leishmaniasis (VL) is a major problem worldwide and causes significant morbidity and mortal...

Anti-leishmanial activity and selectivity indexes of phenolic compounds on amastigotes.

Christine Achiaa Antwi (6397193)
Cynthia Mmalebna Amisigo (6397196)
Jonathan Partt Adjimani (6397199)
Theresa Manful Gwira (4459087)

March 2019

Anti-leishmanial activity and selectivity indexes of phenolic compounds on amastigotes.</p

In vitro activity against L. donovani in IC50 (μM) of compounds fulfilling hit criteria.

Marcel Kaiser (41510)
Pascal Mäser (87895)
Leela Pavan Tadoori (782938)
Jean-Robert Ioset (115415)
Reto Brun (41511)

August 2015

aL. don. axen.: axenic amastigotes of L. donovani, ...

Journal ojAntimicrobial Chemotherapy (1984) 14,463^475 An in-vitro system for determining the activity of compounds against the intracellular amastigote form of Leishmania donovani

R. A. Neal
S. L. Croft

August 2016

A method has been defined for infecting primary mouse peritoneal macrophages with amastigotes of Lei...

and

H. Abdala
N. Alvarez
F. Delmas
C. Di Giorgio
J. M. Robert
G. Le Baut
P. Le Pape

August 2014

Leishmania mexicana promastigote and intracellular amastigote growths were inhibited by the water-so...

Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity

Nühs, Andrea
De Rycker, Manu
Manthri, Sujatha
Comer, Eamon
Scherer, Christina A.
Schreiber, Stuart L.
Ioset, Jean-Robert
Gray, David Michael

February 2017

Visceral leishmaniasis is an important parasitic disease of the developing world with a limited arse...

Using a non-image-based medium-throughput assay for screening compounds targeting n-myristoylation in intracellular leishmania amastigotes

Paape, Daniel
Bell, Andrew S.
Heal, William P.
Hutton, Jennie A.
Leatherbarrow, Robin J.
Tate, Edward W.
Smith, Deborah F.

January 2014

We have refined a medium-throughput assay to screen hit compounds for activity against N-myristoylat...

Amastigotes: Application to Anti-leishmanial Drug Discovery

Aulner Nathalie
Danckaert Anne
Rouault-Hardoin Eline
Desrivot Julie
Helynck Olivier
Commere Pierre-Henri
Munier-Lehmann Hélène
Späth Gerald F.
Shorte Spencer L.
Milon Geneviève
Prina Eric

April 2013

amastigotes that develop and proliferate inside macrophages, thereby causing the pathology of leish...

Using a Non-Image-Based Medium-Throughput Assay for Screening Compounds Targeting N-myristoylation in Intracellular Leishmania Amastigotes

Paape, Daniel
Bell, Andrew S
Heal, William P
Hutton, Jennie A
Leatherbarrow, Robin J
Tate, Edward W
Smith, Deborah F

December 2014

We have refined a medium-throughput assay to screen hit compounds for activity against N-myristoylat...

Trypanocidal and leishmanicidal activities of cytochalasins A–D against intracellular T. cruzi Tulahuen LacZ and L. infantum amastigotes and cytotoxicity for fibroblasts (HFF-1), human macrophages (THP-1) and hepatocytes (HepG2).

Marilia Valli (6091874)
Julia Medeiros Souza (13899274)
Rafael Consolin Chelucci (10178764)
Carolina Rabal Biasetto (13899277)
Angela Regina Araujo (2188726)
Vanderlan da Silva Bolzani (1760392)
Adriano Defini Andricopulo (3133146)

October 2022

Trypanocidal and leishmanicidal activities of cytochalasins A–D against intracellular T. cruzi Tulah...

Development and validation of a novel Leishmania donovani screening cascade for high-throughput screening using a novel axenic assay with high predictivity of Leishmanicidal intracellular activity

Nühs, Andrea
De Rycker, Manu
Manthri, Sujatha
Comer, Eamon
Scherer, Christina A.
Schreiber, Stuart L.
Ioset, Jean-Robert
Gray, David W.

September 2015

Visceral leishmaniasis is an important parasitic disease of the developing world with a limited arse...

Identification of sialic acids on Leishmania donovani amastigotes

Chava, A. K.
Chatterjee, M.
Gerwig, G. J.
Kamerling, J. P.
Mandal, C.

January 2004

The presence of Neu5Ac on promastigotes of Leishmania donovani, the causative organism of Indian vis...

N-251 selectively exhibits leishmanicidal activity against <i>L</i>. <i>donovani</i> D10 intracellular amastigotes.

Abstract

Extracted data

N-251 selectively exhibits leishmanicidal activity against <i>L</i>. <i>donovani</i> D10 intracellular amastigotes.

Abstract

Extracted data

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