Analysis of tumor infiltrated lymphocytes (TIL) in mouse sarcoma model under HPK1 WT and KD background.
- Jinqi Liu (288494)
- Joshua Curtin (6508484)
- Dan You (1551370)
- Stephen Hillerman (6508487)
- Bifang Li-Wang (85432)
- Rukiye Eraslan (6508490)
- Jenny Xie (153871)
- Jesse Swanson (5877005)
- Ching-Ping Ho (5877008)
- Simone Oppenheimer (2338168)
- Bethanne M. Warrack (1436392)
- Colleen A. McNaney (6508493)
- David M. Nelson (101515)
- Jordan Blum (5347976)
- Taeg Kim (6508496)
- Mark Fereshteh (6508499)
- Michael Reily (6508502)
- Petia Shipkova (3944456)
- Anwar Murtaza (6508505)
- Miguel Sanjuan (6508508)
- John T. Hunt (1601446)
- Luisa Salter-Cid (1429873)
Publication date
March 2019
DOI Publisher
Public Library of Science (PLoS)Abstract
TILs were isolated after 10 days of tumor implantation. A. Tumor progression at day 5 and day 10 post tumor implantation. B. Ratio of CD8+/Treg in tumors from WT and KD mice. CD45+ TILs were analyzed by FACS. C. The percentage of CD8+Ki67+ T cells from tumors determined by FACS. D. The percentage of regulatory T cells in tumors as defined by CD4+CD25hiFOXP3+. E. The percentage of CD8+Ki67+ T cells from dLN. Single cell suspension was generated from tumor dLN and analyzed by FACS. F. The percentage of CD4+Ki67+ T cells from dLN. G. The percentage of regulatory T cells from tumor dLN as defined by CD4+CD25hiFOXP3+. N = 15 per group.</p
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