Titers of the anti-<i>Leishmania (L</i>.<i>) infantum</i> immunoglobulin G1 (IgG1) and IgG3 in visceral leishmaniasis (VL) patients during clinical follow up.

(A and C) IgG1 and IgG3 levels of VL patients in the active phase, after one-month post-treatment (1 mpt) and in healthy volunteers. (B and D) The insert shows the IgG1 and IgG3 levels from the same patients prospectively evaluated in two different time points (n = 22). Each symbol represents one patient. The horizontal bar represents the median values. Asterisks denote a statistically significant difference between groups, *p<0.05; ***p<0.0001.