EGFR inhibitor sensitivity on selected pancreatic adenocarcinoma cell lines.

PDAC cells were treated with the indicated concentrations of gefitinib for 6 days and cell viability was measured by MTT assay. (A) Gefitinib insensitive cells. Monophasic curves were generated for gefitinib insensitive MTT data. (B) Gefitinib activated cells. No curve was generated for gefitinib activated cells; (C) Gefitinib sensitive cells. A biphasic curve was generated for gefitinib sensitive MTT data. PDAC cells were treated with the indicated concentrations of cetuximab for 6 days and cell viability was measured by MTT assay. (D) Cetuximab insensitive cells. No curve was generated for cetuximab insensitive cells. (E) Cetuximab sensitive cells. Monophasic curves were generated for cetuximab sensitive MTT data. Assays were completed in triplicate.