In this study, the time-dependent evolution of amorphous probucol nanoparticles was characterized by cryogenic transmission electron microscopy (cryo-TEM) and atomic force microscopy (AFM). The nanoparticles were formed by dispersing ternary solid dispersions of probucol in water. Spray drying and cogrinding were used to prepare a spray-dried sample (SPD) and two ground-mixture samples (GM(I) and GM(II)) of probucol (PBC) form I and form II/hypromellose/sodium dodecyl sulfate ternary solid dispersions. The amorphization of PBC in the SPDs and GMs was confirmed using powder X-ray diffraction (PXRD) and solid-state 13C nuclear magnetic resonance (NMR) spectroscopy. Additionally, differential scanning calorimetry showed that relatively small...
To improve the dissolution behavior of lipophilic drugs, a novel bottom-up process based upon freeze...
To improve the dissolution behavior of lipophilic drugs, a novel bottom-up process based upon freeze...
Crystals of a particular size and habit can be engineered by manipulating crystallisation process co...
The crystallization behavior of a pharmaceutical drug in nanoparticles was directly evaluated by ato...
To elucidate the aqueous solubility enhancement mechanism of solid dispersions (SDs), metastable ble...
The impact of residual drug crystals that are formed during the production and storage of amorphous ...
The morphology and stability of amorphous nanoparticles of glibenclamide (GLB) prepared by the antis...
The bioavailability of hydrophobic drugs strongly increases if they are formulated as amorphous mate...
Approximately 40% of the drugs dissolve poorly in the gastro-intestinal tract after oral administrat...
In this work, the effect of stabilizer choice and concentration was investigated on nanoparticle (NP...
Anti-solvent precipitation produced sub-100 nm [Greek small letter beta]-carotene (BCN) particles de...
Amorphous solid dispersions over the last decade or so have been widely investigated by the pharmace...
One of the benefits of nanocrystals is their positive effect on the solubility and dissolution rate ...
AbstractPLGA/PLA polymeric nanoparticles could potentially enhance the effectiveness of convective d...
The use of nanoparticles as drug carriers for pulmonary delivery of medicines is advantageous as the...
To improve the dissolution behavior of lipophilic drugs, a novel bottom-up process based upon freeze...
To improve the dissolution behavior of lipophilic drugs, a novel bottom-up process based upon freeze...
Crystals of a particular size and habit can be engineered by manipulating crystallisation process co...
The crystallization behavior of a pharmaceutical drug in nanoparticles was directly evaluated by ato...
To elucidate the aqueous solubility enhancement mechanism of solid dispersions (SDs), metastable ble...
The impact of residual drug crystals that are formed during the production and storage of amorphous ...
The morphology and stability of amorphous nanoparticles of glibenclamide (GLB) prepared by the antis...
The bioavailability of hydrophobic drugs strongly increases if they are formulated as amorphous mate...
Approximately 40% of the drugs dissolve poorly in the gastro-intestinal tract after oral administrat...
In this work, the effect of stabilizer choice and concentration was investigated on nanoparticle (NP...
Anti-solvent precipitation produced sub-100 nm [Greek small letter beta]-carotene (BCN) particles de...
Amorphous solid dispersions over the last decade or so have been widely investigated by the pharmace...
One of the benefits of nanocrystals is their positive effect on the solubility and dissolution rate ...
AbstractPLGA/PLA polymeric nanoparticles could potentially enhance the effectiveness of convective d...
The use of nanoparticles as drug carriers for pulmonary delivery of medicines is advantageous as the...
To improve the dissolution behavior of lipophilic drugs, a novel bottom-up process based upon freeze...
To improve the dissolution behavior of lipophilic drugs, a novel bottom-up process based upon freeze...
Crystals of a particular size and habit can be engineered by manipulating crystallisation process co...