Number of drugs above MIC by lesion type.

Number of drugs above MIC over time plot of first-line drugs at steady state, collected as the fifth percentile (low-exposure or at-risk patients) of 1,000 simulated patients over the 24-h dosing interval. Each square represents 1 h that a drug is above the MIC. The drugs are stacked for each hour with different colors representing different drugs. Empty squares show no drug on board. MIC, minimum inhibitory concentration.