MiR-4524b-5p enhanced metastasis ability of human cervical cancer cells in vivo.

(A) Examination of tumorigenesis in animals subcutaneously injected with SiHa cells stably expressing the negative control or miR-4524b-5p. (B) The tumor growth curve of miR-4524b-5p-expressing cells was compared with that of negative control cells. (C) The tumor weight of miR-4524b-5p-expressing cells was compared with that of negative control cells. (D) Mouse abdominal metastatic tumor model (5 mice in each group). Representative photos of abdominal metastatic nodules are indicated by red arrows. (E) The abdomen tumor weight of miR-4524b-5p-expressing cells was compared with that of negative control cells. (F) The metastasis implants of miR-4524b-5p-expressing cells were compared with those of negative control cells. All data are presented as the means ± SEM, *P P < 0.001.