The Citrate Lyase (ACL) is the main cytosolic enzyme that converts the citrate exported from mitochondria by the SLC25A1 carrier in Acetyl Coenzyme A (acetyl-CoA) and oxaloacetate. Acetyl-CoA is a high-energy intermediate common to a large number of metabolic processes including protein acetylation reactions. This renders ACL a key regulator of histone acetylation levels and gene expression in diverse organisms including humans. We have found that depletion of ATPCL, the Drosophila ortholog of human ACL, reduced levels of Acetyl CoA but, unlike its human counterpart, does not affect global histone acetylation and gene expression. Nevertheless, reduced ATPCL levels caused evident, although moderate, mitotic chromosome breakage suggesting tha...
The metabolite acetyl-CoA is necessary in almost all organic life. Cytosolic acetyl-CoA is crucial f...
SummaryMechanisms of metabolic flexibility enable cells to survive under stressful conditions and ca...
A variety of human genetic diseases is known to be caused by mutations in genes encoding chromatin f...
The Citrate Lyase (ACL) is the main cytosolic enzyme that converts the citrate exported from mitocho...
The Citrate Lyase (ACL) is the main cytosolic enzyme that converts the citrate exported from mitocho...
The Citrate Lyase (ACL) is the main cytosolic enzyme that converts the citrate exported from mitocho...
The Drosophila melanogasterDmATPCL gene encodes for the human ATP Citrate Lyase (ACL) ortholog, a me...
Maintaining genomic integrity and sustaining bioenergetics are both fundamental biological functions...
Maintaining genomic integrity and sustaining bioenergetics are both fundamental biological functions...
Histone acetylation plays essential roles in cell cycle progression, DNA repair, gene expression and...
While maintaining the integrity of the genome and sustaining bioenergetics are both fundamental func...
International audienceAcross different kingdoms of life, ATP citrate lyase (ACLY, also known as ACL)...
The metabolite acetyl-CoA is necessary in almost all organic life. Cytosolic acetyl-CoA is crucial f...
Contains fulltext : 129327.pdf (Publisher’s version ) (Open Access)ATP-dependent c...
In eukaryotes, de novo fatty acid and cholesterol synthesis occurs in the cytosol. The production of...
The metabolite acetyl-CoA is necessary in almost all organic life. Cytosolic acetyl-CoA is crucial f...
SummaryMechanisms of metabolic flexibility enable cells to survive under stressful conditions and ca...
A variety of human genetic diseases is known to be caused by mutations in genes encoding chromatin f...
The Citrate Lyase (ACL) is the main cytosolic enzyme that converts the citrate exported from mitocho...
The Citrate Lyase (ACL) is the main cytosolic enzyme that converts the citrate exported from mitocho...
The Citrate Lyase (ACL) is the main cytosolic enzyme that converts the citrate exported from mitocho...
The Drosophila melanogasterDmATPCL gene encodes for the human ATP Citrate Lyase (ACL) ortholog, a me...
Maintaining genomic integrity and sustaining bioenergetics are both fundamental biological functions...
Maintaining genomic integrity and sustaining bioenergetics are both fundamental biological functions...
Histone acetylation plays essential roles in cell cycle progression, DNA repair, gene expression and...
While maintaining the integrity of the genome and sustaining bioenergetics are both fundamental func...
International audienceAcross different kingdoms of life, ATP citrate lyase (ACLY, also known as ACL)...
The metabolite acetyl-CoA is necessary in almost all organic life. Cytosolic acetyl-CoA is crucial f...
Contains fulltext : 129327.pdf (Publisher’s version ) (Open Access)ATP-dependent c...
In eukaryotes, de novo fatty acid and cholesterol synthesis occurs in the cytosol. The production of...
The metabolite acetyl-CoA is necessary in almost all organic life. Cytosolic acetyl-CoA is crucial f...
SummaryMechanisms of metabolic flexibility enable cells to survive under stressful conditions and ca...
A variety of human genetic diseases is known to be caused by mutations in genes encoding chromatin f...