We report a concise chemoenzymatic synthesis of podophyllotoxin. Highlights of the synthesis include the use of enzymatic oxidative coupling to generate the tetracyclic core of the natural product, and late stage chemical oxidation to install the requisite secondary alcohol
Podophyllotoxin is a lignan that occurs in several plant species. Its cytotoxic activity is well-kno...
The new 3-ethyl carboxy-4-phenyl-6-fluoro-1-tetralone and 3-ethyl carboxy-4-(p-anisyl)-6-fluoro-1-te...
Since 1960, only seven plant-derived anticancer drugs have received FDA approval for commercial prod...
Podophyllotoxin is an aryl tetralin lignan isolated from the plants Podophyllum peltatum and Podophy...
Podophyllotoxin derivatives like etoposide, etophos , and teniposide are used clinically as potent ...
Podophyllotoxin derivatives like etoposide 7a, etophos 7b, and teniposide 7c are used clinically as ...
Abstract Background The aryltetralin lignan (−)−podophyllotoxin is a potent antiviral and anti-neopl...
A nickel-catalyzed reductive cascade approach to the efficient construction of diastereodivergent co...
An enantioselective approach via an intramolecular Diels-Alder reaction to the total synthesis of po...
Podophyllotoxin is a lignan natural product that has long been known to possess medicinal properties...
The pharmaceutically important anticancer drugs etoposide and teniposide are derived from podophyllo...
Podophyllotoxin-based glycosidic derivatives have seen numerous uses in cancer chemotherapy. However...
Asymmetric synthesis of podophyllotoxin is achieved through tandem conjugate addition of S (-) benzy...
Abstract: The meso diacetate, 9, available in seven steps from piperonal, is efficiently desymmetriz...
Approaches to podophyllotoxin 1c involving electrophilic ring closure as the crucial step have until...
Podophyllotoxin is a lignan that occurs in several plant species. Its cytotoxic activity is well-kno...
The new 3-ethyl carboxy-4-phenyl-6-fluoro-1-tetralone and 3-ethyl carboxy-4-(p-anisyl)-6-fluoro-1-te...
Since 1960, only seven plant-derived anticancer drugs have received FDA approval for commercial prod...
Podophyllotoxin is an aryl tetralin lignan isolated from the plants Podophyllum peltatum and Podophy...
Podophyllotoxin derivatives like etoposide, etophos , and teniposide are used clinically as potent ...
Podophyllotoxin derivatives like etoposide 7a, etophos 7b, and teniposide 7c are used clinically as ...
Abstract Background The aryltetralin lignan (−)−podophyllotoxin is a potent antiviral and anti-neopl...
A nickel-catalyzed reductive cascade approach to the efficient construction of diastereodivergent co...
An enantioselective approach via an intramolecular Diels-Alder reaction to the total synthesis of po...
Podophyllotoxin is a lignan natural product that has long been known to possess medicinal properties...
The pharmaceutically important anticancer drugs etoposide and teniposide are derived from podophyllo...
Podophyllotoxin-based glycosidic derivatives have seen numerous uses in cancer chemotherapy. However...
Asymmetric synthesis of podophyllotoxin is achieved through tandem conjugate addition of S (-) benzy...
Abstract: The meso diacetate, 9, available in seven steps from piperonal, is efficiently desymmetriz...
Approaches to podophyllotoxin 1c involving electrophilic ring closure as the crucial step have until...
Podophyllotoxin is a lignan that occurs in several plant species. Its cytotoxic activity is well-kno...
The new 3-ethyl carboxy-4-phenyl-6-fluoro-1-tetralone and 3-ethyl carboxy-4-(p-anisyl)-6-fluoro-1-te...
Since 1960, only seven plant-derived anticancer drugs have received FDA approval for commercial prod...
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