The interaction between T cells and cleaved OPN can be blocked with monoclonal antibodies.
- Bettina Wanko (669358)
- Matteo Tardelli (2163007)
- Alexander Jürets (355975)
- Angelika Neuhofer (2163010)
- Gerhard Prager (552088)
- John Morser (142094)
- Lawrence L. Leung (6560342)
- Günther Staffler (2163013)
- Maximilian Zeyda (277119)
- Thomas M. Stulnig (277121)
Publication date
April 2019
DOI Publisher
Public Library of Science (PLoS)Abstract
(A-C) Blockade of the interaction of primary human T cells with OPN with monoclonal antibodies 21–5 and 9–3. 1 experiment, 2 donors, each run in duplicate (A) Blockade of T cell binding to FL-OPN. (B) Blockade of T cell binding to Thr-cOPN. (C) Blockade of T cell binding to MMP-cOPN; mean ± SEM depicted; Comparison with the isotype control antibody; * p < 0.05, ** p < 0.01 and *** p < 0.001; **** p < 0.0001.</p
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