Excessive blood vessel formation in the eye is implicated in wet age-related macular degeneration, proliferative diabetic retinopathy, neovascular glaucoma, and retinopathy of prematurity, which are major causes of blindness. Small molecule antiangiogenic drugs are strongly needed to supplement existing biologics. Homoisoflavonoids have been previously shown to have potent antiproliferative activities in endothelial cells over other cell types. Moreover, they demonstrated a strong antiangiogenic potential in vitro and in vivo in animal models of ocular neovascularization. Here, we tested the antiangiogenic activity of a group of naturally occurring homoisoflavonoids isolated from the family Hyacinthaceae and related synthetic compounds, cho...
Neovascular eye diseases are a major cause of blindness. Excessive angiogenesis is a feature of seve...
Ocular neovascularisation underlies blinding eye diseases such as retinopathy of prematurity, prolif...
An imbalance of angiogenesis contributes to many pathologies such as cancer, arthritis and retinopat...
Excessive blood vessel formation in the eye is implicated in wet age-related macular degeneration, p...
Pathogenic neovascularization underlies a number of degenerative ocular diseases, which together are...
Background Homoisoflavonoids have been shown to have potent anti-proliferative activities in endoth...
<div><p>Preventing pathological ocular angiogenesis is key to treating retinopathy of prematurity, d...
Eye diseases characterized by excessive angiogenesis such as wet age-related macular degeneration, p...
Eye diseases characterized by excessive angiogenesis such as wet age-related macular degeneration, p...
Natural products are characterized by high chemical diversity and biochemical specificity; therefore...
Background: Homoisoflavonoids have been shown to have potent anti-proliferative activities in end...
A naturally occurring homoisoflavonoid, cremastranone (1) inhibited angiogenesis in vitro and in viv...
Angiogenesis is a process of new blood vessels sprouting from the pre-existing vasculature, and medi...
Neovascularization in the eye is the most common cause of blindness in all age groups; retinopathy o...
Chalcones are precursors of flavonoid biosynthesis in plants. Both flavonoids and chalcones are inte...
Neovascular eye diseases are a major cause of blindness. Excessive angiogenesis is a feature of seve...
Ocular neovascularisation underlies blinding eye diseases such as retinopathy of prematurity, prolif...
An imbalance of angiogenesis contributes to many pathologies such as cancer, arthritis and retinopat...
Excessive blood vessel formation in the eye is implicated in wet age-related macular degeneration, p...
Pathogenic neovascularization underlies a number of degenerative ocular diseases, which together are...
Background Homoisoflavonoids have been shown to have potent anti-proliferative activities in endoth...
<div><p>Preventing pathological ocular angiogenesis is key to treating retinopathy of prematurity, d...
Eye diseases characterized by excessive angiogenesis such as wet age-related macular degeneration, p...
Eye diseases characterized by excessive angiogenesis such as wet age-related macular degeneration, p...
Natural products are characterized by high chemical diversity and biochemical specificity; therefore...
Background: Homoisoflavonoids have been shown to have potent anti-proliferative activities in end...
A naturally occurring homoisoflavonoid, cremastranone (1) inhibited angiogenesis in vitro and in viv...
Angiogenesis is a process of new blood vessels sprouting from the pre-existing vasculature, and medi...
Neovascularization in the eye is the most common cause of blindness in all age groups; retinopathy o...
Chalcones are precursors of flavonoid biosynthesis in plants. Both flavonoids and chalcones are inte...
Neovascular eye diseases are a major cause of blindness. Excessive angiogenesis is a feature of seve...
Ocular neovascularisation underlies blinding eye diseases such as retinopathy of prematurity, prolif...
An imbalance of angiogenesis contributes to many pathologies such as cancer, arthritis and retinopat...