There is overwhelming evidence for an association between impaired mitochondrial function and metabolic syndrome. Mitophagy, a process that selectively removes damaged mitochondria via a specialized form of autophagy, is essential for mitochondrial quality control (mitochondrial QC) and metabolic homeostasis. We thus addressed the potential role of defective mitophagy in the pathogenesis of metabolic disorders. Mice lacking Fundc1, a newly characterized mitophagy receptor, develop more severe obesity and insulin resistance when fed a high-fat diet (HFD). Ablation of Fundc1 results in defective mitophagy and impaired mitochondrial QC in vitro and in white adipose tissue (WAT). In addition, there is more pronounced WAT remodeling with more ad...
Autophagy, which is critical for the proper turnover of organelles such as endoplasmic reticulum and...
SummaryObesity and type 2 diabetes are associated with mitochondrial dysfunction in adipose tissue, ...
Obesity and type 2 diabetes are associated with mitochondrial dysfunction in adipose tissue, but the...
Summary: The quality of mitochondria in skeletal muscle is essential for maintaining metabolic homeo...
Abstract Metabolic syndrome (MS), a chronic and non‐communicable pathological condition, is characte...
Although macroautophagy/autophagy deficiency causes degenerative diseases, the deletion of essential...
Mitochondrial dysfunction in adipose tissue occurs in obesity, type 2 diabetes, and some forms of li...
Abstract Background Obesity-mediated oxidative stress results in mitochondrial dysfunction, which ha...
Mitochondrial dysfunction in adipose tissue occurs in obesity, type 2 diabetes, and some forms of li...
High-fat diet (HFD) and inflammation are the key contributors to insulin resistance and type 2 diabe...
International audienceThe metabolic syndrome covers metabolic abnormalities including obesity and ty...
Mitochondria (Mt) are essential cellular organelles for the production of energy and thermogenesis. ...
Background & Aims: Obesity promotes the development of nonalcoholic fatty liver diseases (NAFLDs), y...
Objective: Studies have shown a correlation between obesity and mitochondrial calcium homeostasis, y...
AbstractHigh-fat diet (HFD) and inflammation are the key contributors to insulin resistance and type...
Autophagy, which is critical for the proper turnover of organelles such as endoplasmic reticulum and...
SummaryObesity and type 2 diabetes are associated with mitochondrial dysfunction in adipose tissue, ...
Obesity and type 2 diabetes are associated with mitochondrial dysfunction in adipose tissue, but the...
Summary: The quality of mitochondria in skeletal muscle is essential for maintaining metabolic homeo...
Abstract Metabolic syndrome (MS), a chronic and non‐communicable pathological condition, is characte...
Although macroautophagy/autophagy deficiency causes degenerative diseases, the deletion of essential...
Mitochondrial dysfunction in adipose tissue occurs in obesity, type 2 diabetes, and some forms of li...
Abstract Background Obesity-mediated oxidative stress results in mitochondrial dysfunction, which ha...
Mitochondrial dysfunction in adipose tissue occurs in obesity, type 2 diabetes, and some forms of li...
High-fat diet (HFD) and inflammation are the key contributors to insulin resistance and type 2 diabe...
International audienceThe metabolic syndrome covers metabolic abnormalities including obesity and ty...
Mitochondria (Mt) are essential cellular organelles for the production of energy and thermogenesis. ...
Background & Aims: Obesity promotes the development of nonalcoholic fatty liver diseases (NAFLDs), y...
Objective: Studies have shown a correlation between obesity and mitochondrial calcium homeostasis, y...
AbstractHigh-fat diet (HFD) and inflammation are the key contributors to insulin resistance and type...
Autophagy, which is critical for the proper turnover of organelles such as endoplasmic reticulum and...
SummaryObesity and type 2 diabetes are associated with mitochondrial dysfunction in adipose tissue, ...
Obesity and type 2 diabetes are associated with mitochondrial dysfunction in adipose tissue, but the...