Aspergillosis is difficult to treat and carries a high mortality rate in immunocompromised patients. Neutrophils play a critical role in control of infection but may be diminished in number and function during immunosuppressive therapies. Here, we measure the effect of three bifunctional small molecules that target Aspergillus fumigatus and prime neutrophils to generate a more effective response against the pathogen. The molecules combine two moieties joined by a chemical linker: a targeting moiety (TM) that binds to the surface of the microbial target, and an effector moiety (EM) that interacts with chemoattractant receptors on human neutrophils. We report that the bifunctional compounds enhance the interactions between primary human neutr...
Invasive aspergillosis (IA), primarily caused by Aspergillus fumigatus, is an opportunistic fungal i...
The secondary metabolome provides pathogenic fungi with a plethoric and versatile panel of molecules...
<p>(A) Imaging of hyphae and neutrophil behavior within interaction channels (i) demonstrates robust...
Aspergillosis is difficult to treat and carries a high mortality rate in immunocompromised patients....
Aspergillosis is difficult to treat and carries a high mortality rate in immunocompromised patients....
Aspergillosis is difficult to treat and carries a high mortality rate in immunocompromised patients....
Aspergillosis is difficult to treat and carries a high mortality rate in immunocompromised patients....
Aspergillosis is difficult to treat and carries a high mortality rate in immunocompromised patients....
Aspergillosis is difficult to treat and carries a high mortality rate in immunocompromised patients....
Neutrophils are known to play a pivotal role in the host defense against Aspergillus infections. Thi...
Neutrophils are one of the most effective antimicrobial cells in the innate immune system. They arri...
Aspergillus fumigatus is an important fungal pathogen and a common cause of invasive fungal infectio...
This work has been supported by the MRC and the University of Aberdeen (MRC Centre for Medical Mycol...
Aspergillus fumigatus is an important airborne fungal pathogen and a major cause of invasive fungal ...
Humans and microbes have a balanced and longstanding relationship. Immunosuppresive therapies and pr...
Invasive aspergillosis (IA), primarily caused by Aspergillus fumigatus, is an opportunistic fungal i...
The secondary metabolome provides pathogenic fungi with a plethoric and versatile panel of molecules...
<p>(A) Imaging of hyphae and neutrophil behavior within interaction channels (i) demonstrates robust...
Aspergillosis is difficult to treat and carries a high mortality rate in immunocompromised patients....
Aspergillosis is difficult to treat and carries a high mortality rate in immunocompromised patients....
Aspergillosis is difficult to treat and carries a high mortality rate in immunocompromised patients....
Aspergillosis is difficult to treat and carries a high mortality rate in immunocompromised patients....
Aspergillosis is difficult to treat and carries a high mortality rate in immunocompromised patients....
Aspergillosis is difficult to treat and carries a high mortality rate in immunocompromised patients....
Neutrophils are known to play a pivotal role in the host defense against Aspergillus infections. Thi...
Neutrophils are one of the most effective antimicrobial cells in the innate immune system. They arri...
Aspergillus fumigatus is an important fungal pathogen and a common cause of invasive fungal infectio...
This work has been supported by the MRC and the University of Aberdeen (MRC Centre for Medical Mycol...
Aspergillus fumigatus is an important airborne fungal pathogen and a major cause of invasive fungal ...
Humans and microbes have a balanced and longstanding relationship. Immunosuppresive therapies and pr...
Invasive aspergillosis (IA), primarily caused by Aspergillus fumigatus, is an opportunistic fungal i...
The secondary metabolome provides pathogenic fungi with a plethoric and versatile panel of molecules...
<p>(A) Imaging of hyphae and neutrophil behavior within interaction channels (i) demonstrates robust...