Recurrent chromosomal and epigenetic alterations in oral squamous cell carcinoma and its putative premalignant condition oral lichen planus - Fig 3

Principal component analysis (A) and hierarchical cluster analysis (B) of OSCC (red spheres and boxes), OLP (blue) and normal controls (green) based on differentially methylated loci (FDR-9, ANOVA, n = 2192 loci). Heatmap (B): blue: low DNA methylation, yellow: high DNA methylation. For presentation purposes, mean DNA methylation values were normalized to zero (mean = 0).