Additional file 7: of Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy

Figure S7. Determination of single dose maximum tolerated dose (MTD). (A) Nu/Nu nude mice were treated with single dose (i.e. 0, 150 mg/kg, 300 mg/kg or 400 mg/kg) KRA-533 via i.p. (n = 6 mice per group). After treatment, the body weight of mice was measured once every other day for 2 weeks. (B) Blood analysis of mice after treatment with single dose(s) of KRA-533. (C) H&E histology of various organs from mice after treatment with single dose(s) of KRA-533. (JPG 1446 kb