Additional file 13: of Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis

Figure S12. Mitochondrial complex I activity in human brain metastases. a Expression levels of complex I subunit NDUFB8 in 197 human brain metastases from different cancers: Carcinoma not otherwise specified (NOS; n = 9), colon cancer (n = 9), breast cancer (n = 25), renal cell cancer (RCC; n = 9), non-small cell lung cancer (NSCLC; n = 52), small cell lung cancer (SCLC; n = 7), melanoma (n = 78) and others (n = 8). H-Score = [staining intensity (1 = weak, 2 = moderate, 3 = strong)] x [frequency of positive cells (%)]. Kruskal-Wallis test with Dunn’s multiple comparisons test: * P < 0.05, ** P < 0.01, **** P < 0.0001 and for comparisons not indicated P ≥ 0.05. b Immunohistochemistry of NDUFB8 in a human melanoma brain metastasis. c Expression levels of complex I subunit NDUFB8 in BRAF mutated melanoma (BRAFV600E; n = 24) and BRAF wild type melanoma (no BRAFV600E; n = 23). Kruskal-Wallis test with Dunn’s multiple comparisons test: n.s.: not significant. (TIFF 12141 kb