Figure S10. Interaction network of β-sitosterol targets and oxidative phosphorylation. The 121 Gene Ontology (GO)-annotated genes implicated in oxidative phosphorylation (red nodes) have 155 experimentally validated protein-protein and protein-DNA interactions involving 141 genes/proteins, including four β-sitosterol targets (green nodes). Purple nodes: Other genes that mediate interactions between β-sitosterol targets and oxidative phosphorylation genes. Interaction directionality is represented with arrows. (TIF 1056 kb
Contains fulltext : 152780.pdf (publisher's version ) (Open Access)BACKGROUND: Num...
Des and 162 edges. Colors of nodes represent Gene Ontology annotations. Supplementary Tables 2 and 3...
Melanoma patients carry a high risk of developing brain metastases, and improvements in survival are...
Figure S9. Interaction network of signature genes and oxidative phosphorylation. The 121 Gene Ontolo...
Figure S7. a Functional classification of the brain metastasis gene signature. Human biological proc...
Figure S8. Protein phosphorylation screening following β-sitosterol treatment. Parallel determinatio...
Figure S6. β-sitosterol treatment effect is not model specific. a Experiment overview. Mice were inj...
Figure S1. The diagram illustrates the step-by-step workflow and analysis strategy used in the curre...
Figure S2. Generation of organ samples for RNA sequencing, brain metastasis gene signature and Conne...
Figure S12. Mitochondrial complex I activity in human brain metastases. a Expression levels of compl...
Figure S3. Cell viability in vitro by increasing β-sitosterol concentrations. Human melanoma cell li...
Figure S5. In vivo validation of β-sitosterol on H1_DL2 brain metastasis. a Initial tumor cell load ...
Figure S11. The respiratory capacity (OCR) in normal melanocytes following β-sitosterol treatment a...
Table S1. Tissue Digestion Protocols. Preparation of Liberase TM Research Grade (Roche Applied Scien...
Figure S4. In vivo efficacy of candidate compounds on H1_DL2 brain metastases. a Left panel: Tumor c...
Contains fulltext : 152780.pdf (publisher's version ) (Open Access)BACKGROUND: Num...
Des and 162 edges. Colors of nodes represent Gene Ontology annotations. Supplementary Tables 2 and 3...
Melanoma patients carry a high risk of developing brain metastases, and improvements in survival are...
Figure S9. Interaction network of signature genes and oxidative phosphorylation. The 121 Gene Ontolo...
Figure S7. a Functional classification of the brain metastasis gene signature. Human biological proc...
Figure S8. Protein phosphorylation screening following β-sitosterol treatment. Parallel determinatio...
Figure S6. β-sitosterol treatment effect is not model specific. a Experiment overview. Mice were inj...
Figure S1. The diagram illustrates the step-by-step workflow and analysis strategy used in the curre...
Figure S2. Generation of organ samples for RNA sequencing, brain metastasis gene signature and Conne...
Figure S12. Mitochondrial complex I activity in human brain metastases. a Expression levels of compl...
Figure S3. Cell viability in vitro by increasing β-sitosterol concentrations. Human melanoma cell li...
Figure S5. In vivo validation of β-sitosterol on H1_DL2 brain metastasis. a Initial tumor cell load ...
Figure S11. The respiratory capacity (OCR) in normal melanocytes following β-sitosterol treatment a...
Table S1. Tissue Digestion Protocols. Preparation of Liberase TM Research Grade (Roche Applied Scien...
Figure S4. In vivo efficacy of candidate compounds on H1_DL2 brain metastases. a Left panel: Tumor c...
Contains fulltext : 152780.pdf (publisher's version ) (Open Access)BACKGROUND: Num...
Des and 162 edges. Colors of nodes represent Gene Ontology annotations. Supplementary Tables 2 and 3...
Melanoma patients carry a high risk of developing brain metastases, and improvements in survival are...