TRAP staining 8 weeks post-OVX (A&E) Fast green and SafO staining of (A) C57BL/6 and (E) p21^-/- mice (B-H) DAPI/TRAP staining.

(C-D and G-H) are magnified images of (B& F) respectively. (I) Osteoclast resorption assay illustrating pit formation by osteoclasts in C57BL/6 and p21-/- mice post-OVX. Both mice groups show similar area of pit formation. Enumeration of TRAP+ cells in (J) bone marrow and (K) cortical bone (L) Number of osteoclasts in the bone marrow measured via flow cytometry.