Overview of average shape similarity between the simulated ellipsoids and a high-resolution reference ellipsoid of 0.1 x 0.1 x 0.1mm.

Volumes (n = 100) by all three raters were up-sampled to the reference resolution to create a conjunct mask between the reference volume and the labeled volume. Columns refer to the orientation of the ellipsoid (parallel, diagonal, and orthogonal to the slice axis). Each block of squares represents sizes and shapes as depicted in Fig 2, with increasing in-plane resolution (0.1 to 2.0mm) from left to the right, and increasing anisotropy (1x to 3x the in-plane voxel size) from top to bottom, with each top row being isotropic. Color intensity indicates the average shape similarity expressed in DCS. Blocks to the right of the dotted line represent DCS scores < 0.75.