Summary of materials and methods.

(A) HR-pQCT-based finite element models were developed to compute (left and right) hip stiffness and strength under loading conditions representative of one-legged stance and of a sideways fall. (B) MicroCT and SAM images from a cross-section of the left tibia midshaft (19.5 ± 3.8 cm away from the knee) of the same donors are used to characterize density and architecture of cortical bone. Microstructural measurements are obtained from a region of the bone that can be reached in vivo by diagnostic ultrasound (red arrow).