Mode of action of HBeAg-induced expansion of mMDSCs in CHB patients.
- Feifei Yang (334047)
- Xueping Yu (14598)
- Chenliang Zhou (703028)
- Richeng Mao (381469)
- Mengqi Zhu (341589)
- Haoxiang Zhu (381465)
- Zhenxuan Ma (6612890)
- Bidisha Mitra (3919016)
- Gan Zhao (4789428)
- Yuxian Huang (381470)
- Haitao Guo (276341)
- Bin Wang (30851)
- Jiming Zhang (381471)
Publication date
April 2019
DOI Publisher
Public Library of Science (PLoS)Abstract
The frequency of circulating mMDSCs is increased in CHB patients in the immune tolerant state. HBeAg induces the expansion of mMDSCs in an IL-6 and IL-1β dependent manner. HBeAg-induced upregulation of IDO expression in mMDSCs dampen T cell functions to promote HBV persistence.</p
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