A model of the miR-451–AMPK–mTOR–cell cycle signaling pathway.

(A) Detailed schematic diagram of cellular decision of proliferation and migration in glioblastoma [40]. (B) Block diagram of the theoretical model representing glucose (G) regulation on miR-451 (M), AMPK (A), mTOR (R) with the signaling pathway to the cell cycle dynamics and the drug (D) suppressing the inhibition of mTOR by AMPK.