Activation of the type I IFN receptor (IFNAR) leads to the formation of the interferon stimulated gene factor 3 complex ISGF3 (STAT1:STAT2:IRF9 complex) which binds to the IFN stimulated response element (ISRE) promoter sequence leading to the activation of various interferon stimulated genes (ISGs) such as <i>isg15</i>, <i>irf7</i> and <i>cxcl10</i>.
- R. Paul Wilson (585128)
- Sarah A. Tursi (3927317)
- Glenn J. Rapsinski (6619841)
- Nicole J. Medeiros (3927314)
- Long S. Le (6619844)
- Kevin P. Kotredes (6619847)
- Sajan Patel (6619850)
- Elisabetta Liverani (430615)
- Shuang Sun (1674031)
- Wenhan Zhu (227950)
- Laurie Kilpatrick (4818120)
- Sebastian E. Winter (133801)
- Ana M. Gamero (6619853)
- Çagla Tükel (45788)
Publication date
April 2019
DOI Publisher
Public Library of Science (PLoS)Abstract
Both IFNAR and IFNGR activation leads to the formation of STAT1 homodimers that bind to GAS sequence leading to the production of additional ISGs.</p
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