EPSP slope after STDP induction under different conditions. A) open red squares: model control (same model data as in Fig 5 open red squares); open green squares: model, with the mBDNF:proBDNF ratio set to 30:70 (instead of 70:30 in control); open black squares: BDNF release reduced to 15 min; closed blue circles: BDNF release compressed to 15 min. B) Solid lines show the concentration in mM of mBDNF over time, dashed lines show the proBDNF. Color coding as in panel A. C) Removal of the RM block (RMBLK in the legend; closed red squares) resulted in 1:4 t-LTP protocol inducing both pre- and post-synaptic t-LTP, with a 50% increase in the overall potentiation. Increasing by 20% the concentration of BDNF inside the vesicles (closed cyan square...
<p>(A, Top) Representative overlapped traces of evoked EPSP/IPSP sequences (ePSP) in the absence of ...
<p><b>A–B</b>. Inhibition of GluN2B restricts the time window of tLTP induction. Representative expe...
Since the first description of spike-timing-dependent plasticity (STDP), different models of STDP ha...
A) Average EPSP slope, calculated from the 18 model synapses (red squares, using a Δt = 5 ms) and ex...
A) Average EPSP slope as a function of time (-10 to 0 min: baseline control). The 70x 1:1 t-LTP prot...
<p>Under the simple STDP model (red curve), potentiation occurs only if the postsynaptic spike falls...
<p><b>A:</b> Amounts of LTP (green) and LTD (red) vs. reward level, with our RSTDP model (solid) and...
<p>(A) Initial and final synaptic weight values across the time interval of LTP simulation (11,000–1...
<p>(A), LFS-induced LTD. Upper plot, LTD was induced by LFS protocol (1 Hz, 900 pulses) at the CA1 d...
<p>(A) The effects of prior EPL stimulation on the subsequent LTP induction were reversed by the int...
A) Membrane potential in a spine during a single induction stimulus (black trace); an EPSPs was trig...
<p>(A, B) 12 TBS-induced L-LTP was reversed by PKMζ inhibitor ZIP. Field EPSP (fEPSP) was evoked in ...
<p>Simulation of the metaplastic triplet STDP rule <a href="http://www.ploscompbiol.org/article/info...
A) Membrane potential in a spine during a single induction stimulus (black trace); an EPSP was trigg...
<p><b>A</b>. Diagram illustrating combined protocols in which pre-LTP protocol follows post-LTP prot...
<p>(A, Top) Representative overlapped traces of evoked EPSP/IPSP sequences (ePSP) in the absence of ...
<p><b>A–B</b>. Inhibition of GluN2B restricts the time window of tLTP induction. Representative expe...
Since the first description of spike-timing-dependent plasticity (STDP), different models of STDP ha...
A) Average EPSP slope, calculated from the 18 model synapses (red squares, using a Δt = 5 ms) and ex...
A) Average EPSP slope as a function of time (-10 to 0 min: baseline control). The 70x 1:1 t-LTP prot...
<p>Under the simple STDP model (red curve), potentiation occurs only if the postsynaptic spike falls...
<p><b>A:</b> Amounts of LTP (green) and LTD (red) vs. reward level, with our RSTDP model (solid) and...
<p>(A) Initial and final synaptic weight values across the time interval of LTP simulation (11,000–1...
<p>(A), LFS-induced LTD. Upper plot, LTD was induced by LFS protocol (1 Hz, 900 pulses) at the CA1 d...
<p>(A) The effects of prior EPL stimulation on the subsequent LTP induction were reversed by the int...
A) Membrane potential in a spine during a single induction stimulus (black trace); an EPSPs was trig...
<p>(A, B) 12 TBS-induced L-LTP was reversed by PKMζ inhibitor ZIP. Field EPSP (fEPSP) was evoked in ...
<p>Simulation of the metaplastic triplet STDP rule <a href="http://www.ploscompbiol.org/article/info...
A) Membrane potential in a spine during a single induction stimulus (black trace); an EPSP was trigg...
<p><b>A</b>. Diagram illustrating combined protocols in which pre-LTP protocol follows post-LTP prot...
<p>(A, Top) Representative overlapped traces of evoked EPSP/IPSP sequences (ePSP) in the absence of ...
<p><b>A–B</b>. Inhibition of GluN2B restricts the time window of tLTP induction. Representative expe...
Since the first description of spike-timing-dependent plasticity (STDP), different models of STDP ha...