4 x 109 VP of (A) Ad5.HVR2-rH17d’ and Ad5.HVR2-His6 or (B) Ad5.HVR5-rH17d’ and Ad5.HVR5-His6 were intravenously administered via tail vein injection and live BLI was repeatedly performed for 30 days to quantify luciferase expression in mouse livers. All data represent the mean ± SEM (n = 5); +p<0.01 relative to Ad5.HVR2-rH17d’ for all time points and *p<0.001 relative to Ad5.HVR5-rH17d’ for all time points.</p
<p>(A) C57/BL6 mice, (B) Sprague Dawley rats and (C) Wistar rats all at day 30 after injection, (D) ...
<p>(A–B) Expression of luciferase (Luc) and <i>Py</i>CSP-Luc in the liver of mice immunized by HTVI....
<p>A) Bioluminescence experiments, assessing <i>in vivo</i> luciferase activity in the liver region ...
Mice were injected IV with 4x1011 vp/kg of vector, and liver luciferase expression was measured 48 h...
Mice were injected IV with 4x1011 vp/kg of vector, and liver luciferase expression was measured 48 h...
<p>(A + B) Luciferase expression was visualised (A) and quantitatively assessed (B) by whole-body bi...
<p>A single dose of 1×10<sup>11</sup> v.p. of Ad5Luc-1 (open columns) or Ad5Luc1-PK (filled columns)...
2.5 x 109 VP of (A) Ad5.HVR2-rH17d’ and Ad5.HVR2-His6 and (B) Ad5.HVR5-rH17d’ and Ad5.HVR5-His6 were...
<p>(A + B) Luciferase expression was visualised (A) and quantitatively assessed (B) by whole-body bi...
(A) Baseline infectivity of the Ad5 vectors was established by incubating TIB76 liver cells with rH1...
<p>Serum luciferase levels were measured 48 hours after 6-week old ICR mice (n = 5 animals per group...
<p>C57BL/6 mice were injected with 1×10e10 vg/animal of several most efficient mutant scAAV vectors ...
<p>Luciferase activity was measured <i>in vivo</i> in five major organs 48 h after intravenous admin...
<p>A) BLI of <i>Trp53/Pten</i> mice injected either SQ or IM with Ad CMV-Cre. Mice were injected wit...
Mice were injected IV with luciferase-expressing HD-Ad vectors at a dose of 4x1011 vp/kg. Mice were ...
<p>(A) C57/BL6 mice, (B) Sprague Dawley rats and (C) Wistar rats all at day 30 after injection, (D) ...
<p>(A–B) Expression of luciferase (Luc) and <i>Py</i>CSP-Luc in the liver of mice immunized by HTVI....
<p>A) Bioluminescence experiments, assessing <i>in vivo</i> luciferase activity in the liver region ...
Mice were injected IV with 4x1011 vp/kg of vector, and liver luciferase expression was measured 48 h...
Mice were injected IV with 4x1011 vp/kg of vector, and liver luciferase expression was measured 48 h...
<p>(A + B) Luciferase expression was visualised (A) and quantitatively assessed (B) by whole-body bi...
<p>A single dose of 1×10<sup>11</sup> v.p. of Ad5Luc-1 (open columns) or Ad5Luc1-PK (filled columns)...
2.5 x 109 VP of (A) Ad5.HVR2-rH17d’ and Ad5.HVR2-His6 and (B) Ad5.HVR5-rH17d’ and Ad5.HVR5-His6 were...
<p>(A + B) Luciferase expression was visualised (A) and quantitatively assessed (B) by whole-body bi...
(A) Baseline infectivity of the Ad5 vectors was established by incubating TIB76 liver cells with rH1...
<p>Serum luciferase levels were measured 48 hours after 6-week old ICR mice (n = 5 animals per group...
<p>C57BL/6 mice were injected with 1×10e10 vg/animal of several most efficient mutant scAAV vectors ...
<p>Luciferase activity was measured <i>in vivo</i> in five major organs 48 h after intravenous admin...
<p>A) BLI of <i>Trp53/Pten</i> mice injected either SQ or IM with Ad CMV-Cre. Mice were injected wit...
Mice were injected IV with luciferase-expressing HD-Ad vectors at a dose of 4x1011 vp/kg. Mice were ...
<p>(A) C57/BL6 mice, (B) Sprague Dawley rats and (C) Wistar rats all at day 30 after injection, (D) ...
<p>(A–B) Expression of luciferase (Luc) and <i>Py</i>CSP-Luc in the liver of mice immunized by HTVI....
<p>A) Bioluminescence experiments, assessing <i>in vivo</i> luciferase activity in the liver region ...