Ranking of mutations and prediction of driver mutations based on B-score.

Snapshots from the MutaGene server show the results of analysis of EGFR gene with a Pan-cancer model. (A) Scatterplot with expected mutability versus observed mutational frequencies. (B) Top list of mutations ranked by their B-Scores. (C) EGFR nucleotide and translated protein sequence shows per-nucleotide site mutability per codon mutability as well as mutabilities of nucleotide and codon substitutions (heatmaps). Mutations observed in tumors from ICGC repository are shown as circles colored by their prediction status: Driver, Potential driver, and Passenger. Missense mutation p.Arg252Pro is shown with a blue arrow.