Codon mutability of missense mutations grouped by their experimental effects.

(A) Mutations from the combined dataset were categorized as neutral and non-neutral. Significant differences with p (B) Mutations binned by their reoccurrence frequency in both MSK-IMPACT (green) and COSMIC v85 (blue) cohorts. In both cohorts, reoccurrence frequency of neutral mutations depends on mutability, whereas for non-neutral mutations, reoccurrence frequency does not scale with background mutability.