Syk is a non-receptor tyrosine kinase critically involved in signaling by various immunoreceptors including B-cell-receptors and activating Fc-receptors. We have previously shown that Syk also mediates immunoreceptor-like signals required for the in vitro development and function of osteoclasts. However, the perinatal lethality of Syk−/− mice precluded the analysis of the role of Syk in in vivo bone metabolism. To overcome that problem, we generated mice with osteoclast-specific (SykΔOC) or hematopoietic (SykΔHaemo) Syk deficiency by conditional deletion of Syk using Cre recombinase expressed under the control of the Ctsk or Vav1 promoter, respectively. Micro-CT analysis revealed increased bone trabecular density in both SykΔOC and SykΔHaem...
Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disease mediated by th...
Osteoclasts are highly specialized cells that resorb bone and contribute to bone remodeling. Disease...
SummaryCertain autoimmune diseases result in abnormal bone homeostasis, but association of immunodef...
Syk is a non-receptor tyrosine kinase critically involved in signaling by various immunoreceptors in...
Syk is a non-receptor tyrosine kinase critically involved in signaling by various immunoreceptors in...
Syk is a non-receptor tyrosine kinase critically involved in signaling by various immunoreceptors in...
In this study, we establish that the tyrosine kinase Syk is essential for osteoclast function in vit...
In this study, we establish that the tyrosine kinase Syk is essential for osteoclast function in vit...
Osteoclasts are large multinucleated cells responsible for bone resorption. Excessive inflammatory a...
Osteoclasts are large multinucleated cells responsible for bone resorption. Excessive inflammatory a...
Non-receptor protein tyrosine kinase Syk mediates signal transduction pathways downstream of immunor...
Bone resorption requires the adhesion of osteoclasts to extracellular matrix (ECM) components, a pro...
Objectives: To investigate the role of non-receptor tyrosine kinases (NRTKs) in inflammation-induced...
<p>Autoantibody production and autoantibody-mediated inflammation are hallmarks of a number of autoi...
The nonreceptor protein spleen tyrosine kinase (Syk) is a key mediator of signal transduction in a v...
Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disease mediated by th...
Osteoclasts are highly specialized cells that resorb bone and contribute to bone remodeling. Disease...
SummaryCertain autoimmune diseases result in abnormal bone homeostasis, but association of immunodef...
Syk is a non-receptor tyrosine kinase critically involved in signaling by various immunoreceptors in...
Syk is a non-receptor tyrosine kinase critically involved in signaling by various immunoreceptors in...
Syk is a non-receptor tyrosine kinase critically involved in signaling by various immunoreceptors in...
In this study, we establish that the tyrosine kinase Syk is essential for osteoclast function in vit...
In this study, we establish that the tyrosine kinase Syk is essential for osteoclast function in vit...
Osteoclasts are large multinucleated cells responsible for bone resorption. Excessive inflammatory a...
Osteoclasts are large multinucleated cells responsible for bone resorption. Excessive inflammatory a...
Non-receptor protein tyrosine kinase Syk mediates signal transduction pathways downstream of immunor...
Bone resorption requires the adhesion of osteoclasts to extracellular matrix (ECM) components, a pro...
Objectives: To investigate the role of non-receptor tyrosine kinases (NRTKs) in inflammation-induced...
<p>Autoantibody production and autoantibody-mediated inflammation are hallmarks of a number of autoi...
The nonreceptor protein spleen tyrosine kinase (Syk) is a key mediator of signal transduction in a v...
Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disease mediated by th...
Osteoclasts are highly specialized cells that resorb bone and contribute to bone remodeling. Disease...
SummaryCertain autoimmune diseases result in abnormal bone homeostasis, but association of immunodef...