Experiment 1.

Glibenclamide did not significantly impact (A) core temperature (P = 0.187, group main effect) or (B) activity (P = 0.876, group main effect) after ICH (n = 6 in glibenclamide group, n = 5 in control group). Core temperature (°C) and activity (AU, arbitrary units–detections of animal movement over a receiver [36]) data were taken using implanted telemetry devices. Core temperature and activity averages for each hour were corrected for the same hour of baseline data to account for time of day effects (e.g., circadian rhythms). Rectal temperature was regulated during surgical procedures; the core temperature drop within the first few hours was due to rapid but mild cooling after post-surgical anaesthesia. (C) Bleeding (P = 0.991) and (D) blood glucose (P = 0.763, group main effect) were both unaffected by glibenclamide. Sample sizes were n = 6 in glibenclamide group, n = 5 in control group.