Host T cells impact the density of gland-associated bacteria.

(A) Total CFU/g recovered from WT or TCRβ/δ−/− (TCR KO) mice infected with H. pylori PMSS1 WT for 8 weeks (8–22 mice per group). Gray dotted line, limit of detection; red bars, median. Data represent two independent experiments. Relevant data values are included in S1 Data. (B) Bacteria per gland in antrum and transition zone of WT or TCR KO mice at 8 weeks post-infection. A total of 200–300 glands were analyzed per mouse for both WT and TCR KO groups (five mice per group). Red bars, median. Relevant data values are included in S1 Data. (C) Percentage of colonized glands in the antrum and transition zone of WT or TCR KO mice at 8 weeks post-infection. Bars, median; error bars, interquartile range. Relevant data values are included in S1 Data. (D) Images of antrum of WT or TCR KO mice at 8 weeks post-infection. Scale bar, 80 μm. Statistics: p-values obtained using Mann–Whitney test (panels A–C). **p p p < 0.0001. CFU, colony-forming unit; KO, knockout; TCR, T-cell receptor; WT, wild-type.