The bifunctional chelator S-2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-N,N′,N″,N‴-1,4,7,10-tetraacetate (IB-DOTA) is on paper the most attractive of the commercially available bifunctional chelators for magnetic resonance imaging (MRI) applications. The preserved DOTA scaffold is known to produce extremely kinetically and thermodynamically robust chelates with the Gd3+ ion. Also, ligation through four acetate pendant arms should ensure that the rapid water exchange kinetics so, crucial to the function of an MRI contrast agent are retained. However, upon ligation of the Gd3+ ion, IB-DOTA differentiates into two distinct isomers defined by the positions of the benzylic substituent (corner or side). A relaxometric analysis of th...
Important requirements for exogenous dyes or contrast agents in magnetic resonance imaging (MRI) inc...
Magnetic resonance imaging (MRI) is a medical imaging technique that provides high-resolution images...
ABSTRACT: Important requirements for exogenous dyes or contrast agents in magnetic resonance imaging...
The bifunctional chelator S-2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-N,N′,N″,N‴-1,4...
The bifunctional chelator S-2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-N,N′,N″,N‴-1,4...
The bifunctional chelator IB-DOTA has found use in a range of biomedical applications given its abil...
The bifunctional chelator IB-DOTA has found use in a range of biomedical applications given its abil...
The need for magnetic resonance imaging (MRI) contrast agents with improved relaxivity maintains the...
Gd<sup>3+</sup> chelates of macrocyclic bifunctional chelators (BFCs) can differentiate into two reg...
Gd(3+) chelates of macrocyclic bifunctional chelators (BFCs) can differentiate into two regioisomers...
Chemical exchange saturation transfer (CEST) offers many advantages as a method of generating contra...
The need for MRI contrast agents with improved relaxivity maintains the development of new Gd(III) c...
Three PEGylated derivatives of 1,4,7,10-tetraazacyclododecane-1-((6-amino)hexanoic)-4,7,10-triacetic...
Important requirements for exogenous dyes or contrast agents in magnetic resonance imaging (MRI) inc...
Controlling the water exchange kinetics of macrocyclic Gd(3+) chelates, a key parameter in the desig...
Important requirements for exogenous dyes or contrast agents in magnetic resonance imaging (MRI) inc...
Magnetic resonance imaging (MRI) is a medical imaging technique that provides high-resolution images...
ABSTRACT: Important requirements for exogenous dyes or contrast agents in magnetic resonance imaging...
The bifunctional chelator S-2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-N,N′,N″,N‴-1,4...
The bifunctional chelator S-2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-N,N′,N″,N‴-1,4...
The bifunctional chelator IB-DOTA has found use in a range of biomedical applications given its abil...
The bifunctional chelator IB-DOTA has found use in a range of biomedical applications given its abil...
The need for magnetic resonance imaging (MRI) contrast agents with improved relaxivity maintains the...
Gd<sup>3+</sup> chelates of macrocyclic bifunctional chelators (BFCs) can differentiate into two reg...
Gd(3+) chelates of macrocyclic bifunctional chelators (BFCs) can differentiate into two regioisomers...
Chemical exchange saturation transfer (CEST) offers many advantages as a method of generating contra...
The need for MRI contrast agents with improved relaxivity maintains the development of new Gd(III) c...
Three PEGylated derivatives of 1,4,7,10-tetraazacyclododecane-1-((6-amino)hexanoic)-4,7,10-triacetic...
Important requirements for exogenous dyes or contrast agents in magnetic resonance imaging (MRI) inc...
Controlling the water exchange kinetics of macrocyclic Gd(3+) chelates, a key parameter in the desig...
Important requirements for exogenous dyes or contrast agents in magnetic resonance imaging (MRI) inc...
Magnetic resonance imaging (MRI) is a medical imaging technique that provides high-resolution images...
ABSTRACT: Important requirements for exogenous dyes or contrast agents in magnetic resonance imaging...